Database of Structural Repeats in Proteins



WD40 repeat - WD


WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins.

Link to other db

InterPro:

IPR001680

PROSITE:

PS50082

SMART:

SM00320

Pfam:

PF00400

Number of PDB chains with WD repeat: 1080
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
4RE5
B
Q9YBQ2
Acylamino-acid-releasing enzyme
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100
196-232, 244-282, 283-319
3
0.75
2HU7
A
Q9YBQ2
Acylamino-acid-releasing enzyme
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100
195-232, 244-282, 283-319
3
0.74
1VE7
B
Q9YBQ2
Acylamino-acid-releasing enzyme
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100
195-232, 244-281, 282-319
3
0.76
4RE6
C
Q9YBQ2
Acylamino-acid-releasing enzyme
Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100
196-232, 244-282, 283-319
3
0.74
5YY8
A
Q9Y6Y0
Influenza virus NS1A-binding protein
Homo sapiens (Human)
94-129, 185-223, 232-272, 283-317
4
0.82
4CC9
A
Q9Y4B6
DDB1- and CUL4-associated factor 1 {ECO:0000312|HGNC:HGNC:30911}
Homo sapiens (Human)
1092-1132, 1138-1170, 1180-1214
3
0.79
5AJA
A
Q9Y4B6
DDB1- and CUL4-associated factor 1 {ECO:0000312|HGNC:HGNC:30911}
Homo sapiens (Human)
1092-1132, 1138-1170, 1180-1214
3
0.80
6M91
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
264-303, 309-344, 345-387, 432-466, 517-548
5
0.83
6M92
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-303, 309-344, 349-387, 399-427, 428-467, 472-506, 517-547
7
0.77
6M93
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
264-303, 309-344, 349-387, 432-466, 472-506, 517-547
6
0.80
6M94
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-304, 309-344, 350-386, 399-427, 432-467
5
0.75
6M90
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-303, 309-344, 350-387, 432-466, 472-506
5
0.77
4CY5
A
Q9V3J8
Protein will die slowly
Drosophila melanogaster (Fruit fly)
70-111, 112-153, 154-194, 196-236, 250-280, 295-324, 327-361
7
0.86
4CY3
A
Q9V3J8
Protein will die slowly
Drosophila melanogaster (Fruit fly)
70-111, 112-153, 154-195, 196-236, 250-280, 284-325, 327-361
7
0.88
4LG8
A
Q9UMS4
Pre-mRNA-processing factor 19 {ECO:0000305}
Homo sapiens (Human)
220-261, 263-302, 304-345, 353-388, 395-431, 434-473, 474-504
7
0.86
4UI9
R
Q9UM11
Fizzy-related protein homolog
Homo sapiens (Human)
228-267, 281-309, 312-351, 358-391, 401-437, 446-474
6
0.81
3E5Z
A
Q9RXN3
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / L
25-64, 66-106, 112-152, 223-253
4
0.85
3V64
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
436-464, 470-506, 509-549, 556-589
4
0.78
3V64
C
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
436-464, 470-506, 509-549, 551-588, 600-636
5
0.79
3V65
B
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
436-464, 466-506, 509-549, 551-589, 600-636
5
0.81
3V65
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
436-464, 470-506, 509-549, 607-636
4
0.76
4HDJ
A
Q9HXJ7
Outer membrane protein assembly factor BamB {ECO:0000255|HAMAP-Rule:MF_00923}
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / J
59-93, 229-268, 275-306, 313-348
4
0.77
3OW8
B
Q9GZS3
WD repeat-containing protein 61, N-terminally processed
Homo sapiens (Human)
62-103, 104-145, 146-186, 188-228, 231-270, 272-304
6
0.90
3OW8
A
Q9GZS3
WD repeat-containing protein 61, N-terminally processed
Homo sapiens (Human)
62-103, 104-145, 147-186, 188-228, 230-270, 273-304
6
0.89
3OW8
D
Q9GZS3
WD repeat-containing protein 61, N-terminally processed
Homo sapiens (Human)
73-103, 109-145, 146-186, 188-228, 230-270, 273-304
6
0.84
3OW8
C
Q9GZS3
WD repeat-containing protein 61, N-terminally processed
Homo sapiens (Human)
73-103, 109-145, 146-186, 188-228, 230-270, 273-304
6
0.84
6N31
A
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
187-226, 255-295, 299-334, 341-379
4
0.90
6FBS
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
128-158, 164-199, 200-240, 285-327, 329-370, 372-410
6
0.93
6F9N
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
118-158, 164-199, 200-240, 243-284, 286-324, 340-370, 373-410
7
0.85
6BM0
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
122-158, 164-199, 200-240, 242-279, 286-324, 335-370, 378-412
7
0.82
6DNH
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
118-158, 159-199, 200-240, 249-281, 286-324, 340-370, 373-412
7
0.86
6BLY
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
128-157, 164-199, 200-240, 286-324, 340-369, 373-412
6
0.81
4LG9
A
Q9BZK7
F-box-like/WD repeat-containing protein TBL1XR1
Homo sapiens (Human)
167-201, 228-264, 265-304, 306-346, 347-384, 409-438, 445-481, 482-513
8
0.83
4JSN
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 84-122, 127-165, 168-207, 218-259, 273-309
7
0.85
4JT6
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 83-122, 127-166, 168-207, 218-259, 268-309
7
0.87
4JT5
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 45-81, 88-122, 127-165, 168-207, 218-259, 273-309
7
0.83
4JSX
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 41-81, 84-122, 127-165, 168-207, 218-259, 273-309
7
0.87
4JSX
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 41-81, 84-122, 127-165, 168-207, 218-259, 273-309
7
0.87
4JT5
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 41-81, 88-122, 127-165, 168-207, 218-259, 273-309
7
0.85
5H64
c
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
29-61, 72-113, 115-156
3
0.95
4JT6
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 83-122, 127-166, 168-207, 218-259, 268-309
7
0.87
4JSP
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 41-81, 84-122, 127-165, 168-207, 218-259, 279-309
7
0.86
4JSP
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 41-81, 84-122, 127-165, 168-207, 218-259, 273-309
7
0.87
5H64
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
29-61, 72-113, 115-156
3
0.95
4JSV
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 84-122, 127-165, 168-207, 218-259, 268-309
7
0.87
4JSN
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 84-122, 168-207, 218-259, 268-309
6
0.85
4JSV
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-78, 84-122, 127-165, 168-207, 218-259, 273-309
7
0.85
5FLC
H
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-76, 77-122, 127-165, 173-208, 218-259, 273-309
7
0.82
5FLC
D
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
8-39, 46-76, 77-122, 127-165, 173-208, 218-259, 273-309
7
0.82
4X60
B
Q9BQA1
Methylosome protein 50
Homo sapiens (Human)
80-119, 124-163, 166-205, 211-252, 264-294, 296-328
6
0.85