Database of Structural Repeats in Proteins



WD40 repeat - WD


WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins.

Link to other db

InterPro:

IPR001680

PROSITE:

PS50082

SMART:

SM00320

Pfam:

PF00400

Number of PDB chains with WD repeat: 1080
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
2YMU
A
B2J0I0
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
14-54, 55-95, 100-135, 138-177, 179-218, 219-259, 260-299, 301-341, 346-382, 384-423, 428-464, 465-505, 506-546, 547-577
14
0.89
2YMU
B
B2J0I0
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
14-54, 55-95, 96-135, 137-176, 179-218, 219-259, 260-299, 302-341, 342-382, 383-423, 425-464, 466-505, 506-546, 547-577
14
0.91
3SHF
A
O88879
Apoptotic protease-activating factor 1
Mus musculus (Mouse)
613-652, 655-696, 702-740, 746-782, 805-836, 844-879, 881-920, 961-999, 1008-1041, 1053-1082, 1091-1123, 1125-1164, 1186-1216
13
0.80
3V9F
D
Q8A3A5
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
32-71, 80-119, 140-169, 177-216, 326-355, 377-415, 421-460, 469-503, 509-548, 552-592, 602-635, 645-680
12
0.82
1NR0
A
Q11176
Actin-interacting protein 1
Caenorhabditis elegans
58-94, 106-141, 146-186, 189-228, 237-278, 327-362, 370-404, 414-448, 451-489, 490-529, 534-572, 579-611
12
0.85
5H1J
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 74-105, 108-148, 154-191, 289-319, 378-417, 429-464, 491-519, 535-575, 593-622, 638-678, 681-720
12
0.80
4A2L
C
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
45-79, 96-124, 135-167, 176-209, 214-251, 260-299, 306-335, 354-392, 403-442, 540-568, 583-621, 627-666
12
0.77
3V9F
A
Q8A3A5
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
32-71, 81-120, 140-170, 177-216, 275-305, 327-366, 377-415, 426-460, 469-503, 520-548, 552-592, 597-634
12
0.82
4CI8
A
O00423
Echinoderm microtubule-associated protein-like 1
Homo sapiens (Human)
179-210, 334-368, 380-409, 416-455, 458-498, 501-540, 542-582, 587-623, 629-660, 675-709, 742-776, 782-815
12
0.80
4A2M
D
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
96-124, 135-167, 175-208, 216-250, 259-298, 354-393, 403-442, 460-488, 500-533, 539-568, 582-621, 627-666
12
0.77
6ND4
O
P25635
Periodic tryptophan protein 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
58-94, 99-134, 144-183, 259-299, 354-383, 385-426, 429-469, 471-507, 524-553, 586-616, 676-715
11
0.83
1PGU
B
P46680
Actin-interacting protein 1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25-55, 73-103, 118-151, 162-199, 209-244, 251-291, 375-408, 455-483, 487-527, 550-580, 582-615
11
0.75
3SFZ
A
O88879
Apoptotic protease-activating factor 1
Mus musculus (Mouse)
613-653, 655-696, 702-739, 746-782, 805-836, 844-879, 881-920, 964-999, 1012-1041, 1042-1081, 1125-1164
11
0.82
3JBT
A
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
5TEF
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 150-191, 282-315, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
11
0.85
3JBT
E
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
5TEE
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 150-191, 289-319, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
11
0.84
4A2M
A
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
85-124, 135-167, 175-209, 216-250, 260-299, 307-346, 359-393, 454-488, 500-533, 539-568, 582-615
11
0.76
3JBT
G
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
3JBT
M
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
3JBT
K
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
5H1K
B
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 150-191, 289-320, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
11
0.83
3JBT
I
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
5H3U
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
19-50, 73-105, 118-148, 154-191, 282-320, 378-417, 429-464, 535-574, 593-622, 638-678, 681-720
11
0.82
5H1M
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 73-105, 108-148, 150-191, 289-320, 378-417, 429-464, 535-575, 594-623, 638-678, 681-720
11
0.83
5H3S
B
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 67-105, 108-148, 154-192, 288-325, 378-417, 429-464, 535-575, 593-622, 638-678, 685-720
11
0.80
1PEV
A
Q11176
Actin-interacting protein 1
Caenorhabditis elegans
58-94, 146-186, 189-228, 237-275, 327-362, 370-404, 414-448, 451-489, 500-528, 534-572, 579-611
11
0.84
3JBT
C
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164, 1186-1215
11
0.73
5THA
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 73-105, 108-148, 150-191, 282-323, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
11
0.85
5H1L
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 154-191, 282-320, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
11
0.83
5H3T
C
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 73-105, 108-148, 150-191, 284-319, 378-417, 429-464, 535-575, 594-623, 638-678, 681-720
11
0.84
5WVE
E
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164
10
0.74
4A2L
A
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
39-78, 96-126, 135-167, 216-250, 259-298, 354-393, 403-442, 539-578, 583-620, 628-667
10
0.83
5H3U
B
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 150-191, 378-417, 429-462, 535-574, 593-622, 638-678, 681-720
10
0.84
5H1K
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 67-105, 108-148, 150-191, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
10
0.84
5WVE
G
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164
10
0.74
4CI8
B
O00423
Echinoderm microtubule-associated protein-like 1
Homo sapiens (Human)
179-210, 328-361, 380-409, 416-455, 458-498, 541-582, 587-623, 629-660, 675-709, 782-815
10
0.79
4A2M
C
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
51-79, 96-126, 135-167, 217-251, 264-298, 354-393, 403-442, 460-488, 500-533, 582-621
10
0.76
1PGU
A
P46680
Actin-interacting protein 1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25-55, 67-102, 162-199, 205-244, 251-291, 375-408, 455-483, 487-527, 550-580, 584-613
10
0.77
5N1A
B
G0SCT7
WD_REPEATS_REGION domain-containing protein {ECO:0000259|PROSITE:PS50294}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
38-69, 95-126, 146-178, 184-225, 233-273, 281-313, 333-362, 482-514, 641-672, 689-717
10
0.73
3V9F
C
Q8A3A5
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
32-71, 80-119, 130-169, 177-216, 377-415, 426-460, 469-503, 509-548, 600-635, 645-680
10
0.85
5GXI
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 74-105, 108-148, 150-191, 378-417, 429-464, 535-575, 593-622, 638-678, 681-720
10
0.83
5H3T
D
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 118-148, 154-191, 378-417, 425-462, 535-565, 593-622, 638-678, 681-720
10
0.82
5H3T
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
20-51, 73-105, 108-148, 154-191, 388-417, 429-462, 535-575, 593-622, 638-678, 691-721
10
0.78
5WVE
I
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164
10
0.74
1PI6
A
P46680
Actin-interacting protein 1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
25-55, 67-102, 118-155, 159-199, 209-245, 251-291, 375-408, 487-526, 550-579, 584-613
10
0.80
4A2L
F
Q89YR8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
39-78, 135-166, 176-208, 216-250, 259-297, 354-393, 415-443, 539-568, 583-621, 627-666
10
0.78
3V9F
B
Q8A3A5
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
32-71, 80-119, 140-170, 177-216, 326-365, 377-415, 421-460, 469-503, 509-548, 552-580
10
0.84
5GXH
A
Q8TEQ6
Gem-associated protein 5
Homo sapiens (Human)
18-50, 73-105, 108-148, 154-191, 378-417, 425-464, 535-575, 593-622, 638-678, 681-720
10
0.84
5WVE
K
O14727
Apoptotic protease-activating factor 1 {ECO:0000305}
Homo sapiens (Human)
613-653, 660-695, 710-739, 746-781, 888-920, 932-961, 970-999, 1053-1081, 1084-1123, 1129-1164
10
0.74