Database of Structural Repeats in Proteins



WD40 repeat - WD


WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins.

Link to other db

InterPro:

IPR001680

PROSITE:

PS50082

SMART:

SM00320

Pfam:

PF00400

Number of PDB chains with WD repeat: 1080
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
6R92
L
Q92466
DNA damage-binding protein 2
Homo sapiens (Human)
121-150, 159-196, 202-237, 245-280, 291-327, 395-423
6
0.72
6R90
L
Q92466
DNA damage-binding protein 2
Homo sapiens (Human)
121-150, 155-196, 211-239, 287-327, 395-425
5
0.76
6R8Z
L
Q92466
DNA damage-binding protein 2
Homo sapiens (Human)
121-150, 159-196, 211-239, 241-280, 287-327
5
0.79
6R8Y
L
Q92466
DNA damage-binding protein 2
Homo sapiens (Human)
122-152, 167-210, 211-243, 253-296, 298-334
5
0.93
6OT0
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
58-94, 96-133, 141-181, 183-222, 224-263, 273-308, 310-340
7
0.84
6OIK
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-181, 182-223, 224-264, 268-308
6
0.92
6OIJ
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-133, 141-179, 182-223, 225-264, 268-308, 310-340
7
0.85
6ND4
J
Q04305
U3 small nucleolar RNA-associated protein 15
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
67-97, 100-142, 143-182, 189-229, 230-269
5
0.88
6ND4
O
P25635
Periodic tryptophan protein 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
58-94, 99-134, 144-183, 259-299, 354-383, 385-426, 429-469, 471-507, 524-553, 586-616, 676-715
11
0.83
6ND4
T
Q06078
U3 small nucleolar RNA-associated protein 21
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
134-173, 177-216, 218-257
3
0.93
6ND4
U
P33750
Protein SOF1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
66-107, 178-216, 218-259, 261-301, 303-343, 347-386
6
0.91
6ND4
W
P40055
U3 small nucleolar RNA-associated protein 7
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
114-149, 150-188, 189-227, 231-271, 380-412
5
0.83
6NBI
B
P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Rattus norvegicus (Rat)
53-94, 96-133, 141-181, 183-222, 225-264, 311-340
6
0.87
6NBH
B
P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Rattus norvegicus (Rat)
58-94, 96-133, 141-180, 183-222, 225-264, 311-340
6
0.85
6NBF
B
P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Rattus norvegicus (Rat)
64-94, 96-133, 141-181, 183-222, 225-264, 268-308, 311-340
7
0.84
6N9G
C
P62881
Guanine nucleotide-binding protein subunit beta-5
Mus musculus (Mouse)
66-102, 108-142, 152-192, 204-235, 238-277, 281-321, 323-353
7
0.82
6N9G
D
P62881
Guanine nucleotide-binding protein subunit beta-5
Mus musculus (Mouse)
66-102, 104-142, 152-192, 204-235, 238-277, 281-321, 323-353
7
0.84
6N8S
A
Q6P1M3
LLGL scribble cell polarity complex component 2
Homo sapiens (Human)
33-62, 76-107, 127-169, 191-228, 229-268, 432-464, 513-542, 591-626, 803-834, 857-888
10
0.75
6N4B
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
58-94, 141-180, 183-222, 224-264, 268-307, 310-340
6
0.85
6N31
A
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
187-226, 255-295, 299-334, 341-379
4
0.90
6MZL
F
Q15542
Transcription initiation factor TFIID subunit 5
Homo sapiens (Human)
542-581, 584-623, 625-665, 667-708, 714-749
5
0.89
6MZL
G
Q15542
Transcription initiation factor TFIID subunit 5
Homo sapiens (Human)
542-581, 584-623, 626-665, 667-708, 714-749
5
0.89
6M94
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-304, 309-344, 350-386, 399-427, 432-467
5
0.75
6M93
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
264-303, 309-344, 349-387, 432-466, 472-506, 517-547
6
0.80
6M92
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-303, 309-344, 349-387, 399-427, 428-467, 472-506, 517-547
7
0.77
6M91
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
264-303, 309-344, 345-387, 432-466, 517-548
5
0.83
6M90
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
269-303, 309-344, 350-387, 432-466, 472-506
5
0.77
6M8S
C
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-127, 141-180, 183-222, 224-264, 268-308
6
0.88
6M8S
D
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-127, 141-180, 183-222, 224-264, 268-308
6
0.89
6M8S
G
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-127, 141-180, 183-222, 229-264, 279-308
6
0.81
6M8S
H
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-127, 141-180, 183-222, 224-264, 268-308, 311-340
7
0.85
6M8S
K
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
64-94, 96-127, 141-180, 183-222, 224-264, 268-308
6
0.89
6K1S
B
Q9BQA1
Methylosome protein 50
Homo sapiens (Human)
80-114, 123-163, 176-206, 222-252, 264-294, 296-328
6
0.79
6ID1
E
Q96DI7
U5 small nuclear ribonucleoprotein 40 kDa protein
Homo sapiens (Human)
65-105, 107-147, 150-191, 196-231, 244-272, 288-322, 326-356
7
0.81
6ID1
T
O43660
Pleiotropic regulator 1
Homo sapiens (Human)
202-243, 249-284, 286-327, 328-368, 377-409, 411-451, 465-499
7
0.87
6ID0
E
Q96DI7
U5 small nuclear ribonucleoprotein 40 kDa protein
Homo sapiens (Human)
69-105, 107-148, 150-191, 202-232, 244-272, 288-323, 325-356
7
0.78
6ID0
T
O43660
Pleiotropic regulator 1
Homo sapiens (Human)
202-243, 245-284, 286-327, 328-368, 377-410, 411-451, 461-500
7
0.90
6ID0
W
O60508
Pre-mRNA-processing factor 17
Homo sapiens (Human)
291-323, 330-370, 383-414, 421-456
4
0.79
6ICZ
E
Q96DI7
U5 small nuclear ribonucleoprotein 40 kDa protein
Homo sapiens (Human)
65-106, 107-148, 150-191, 196-232, 244-272, 289-323, 325-356
7
0.81
6ICZ
T
O43660
Pleiotropic regulator 1
Homo sapiens (Human)
202-243, 244-284, 286-327, 329-368, 376-410, 411-451, 460-496
7
0.90
6IAM
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-298, 300-334
7
0.88
6HQA
B
C4R4L4
Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pasto
393-427, 452-491, 494-533, 536-575, 578-617, 620-659
6
0.89
6H0F
D
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
24-56, 258-293, 311-345, 877-906, 910-949, 954-985
6
0.71
6H0F
J
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
24-56, 258-293, 311-345, 877-906, 910-949, 954-985
6
0.71
6GDG
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-181, 182-221, 224-265, 268-309, 310-340
7
0.89
6G90
P
Q04693
Pre-mRNA-splicing factor RSE1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
365-401, 422-452, 595-624, 674-705, 1030-1065, 1074-1110, 1113-1153
7
0.77
6G6Q
A
-
-
-
14-47, 53-87, 93-127
3
0.79
6G6Q
B
-
-
-
14-47, 53-87, 93-127
3
0.78
6G6Q
C
-
-
-
14-47, 53-87, 93-128
3
0.79
6G6Q
D
-
-
-
14-47, 53-87, 93-127
3
0.79