Database of Structural Repeats in Proteins



WD40 repeat - WD


WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins.

Link to other db

InterPro:

IPR001680

PROSITE:

PS50082

SMART:

SM00320

Pfam:

PF00400

Number of PDB chains with WD repeat: 1080
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5AJ0
Bg
-
-
-
46-84, 85-126, 128-170
3
0.95
5A2Q
g
P63244
Receptor of activated protein C kinase 1, N-terminally processed
Homo sapiens (Human)
2-48, 50-95, 96-137
3
0.95
5H64
C
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
29-61, 72-113, 115-156
3
0.95
5H64
c
Q9BVC4
Target of rapamycin complex subunit LST8
Homo sapiens (Human)
29-61, 72-113, 115-156
3
0.95
3JCT
x
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
154-200, 201-244, 246-290
3
0.94
6C23
N
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
129-171, 175-224, 225-274
3
0.94
5IGQ
F
Q8NHY2
E3 ubiquitin-protein ligase COP1 {ECO:0000305}
Homo sapiens (Human)
419-457, 469-509, 512-551, 554-592
4
0.93
1OMW
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-131, 141-180, 182-222, 224-264, 268-309
6
0.93
2FAW
A
O81226
Carica papaya (Papaya)
104-143, 151-189, 204-241
3
0.93
5LCW
R
Q12834
Cell division cycle protein 20 homolog
Homo sapiens (Human)
225-265, 266-306, 312-348
3
0.93
1U4C
B
P26449
Cell cycle arrest protein BUB3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-57, 67-100, 111-153, 160-194, 261-295
5
0.93
6R8Y
L
Q92466
DNA damage-binding protein 2
Homo sapiens (Human)
122-152, 167-210, 211-243, 253-296, 298-334
5
0.93
4J73
A
P41811
Coatomer subunit beta'
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
13-52, 54-94, 95-137, 139-176, 227-267
5
0.93
5WSG
O
Q12417
Pre-mRNA-splicing factor PRP46
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
138-178, 181-220, 223-262, 265-304, 306-345, 348-388, 397-436
7
0.93
6ND4
T
Q06078
U3 small nucleolar RNA-associated protein 21
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
134-173, 177-216, 218-257
3
0.93
6FBS
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
128-158, 164-199, 200-240, 285-327, 329-370, 372-410
6
0.93
6G5I
g
P63244
Receptor of activated protein C kinase 1, N-terminally processed
Homo sapiens (Human)
39-76, 83-121, 125-163, 170-205, 211-246
5
0.92
5HE2
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-180, 182-222, 224-264, 268-308
6
0.92
5TZS
g
Q06506
Ribosomal RNA-processing protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
235-275, 279-318, 320-360, 397-436, 470-507
5
0.92
5HE1
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-134, 141-180, 183-222, 224-264, 268-309
6
0.92
6F1T
o
Q13409
Cytoplasmic dynein 1 intermediate chain 2
Homo sapiens (Human)
302-351, 352-400, 401-450, 462-500
4
0.92
4J0X
B
Q06506
Ribosomal RNA-processing protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
235-275, 279-319, 320-360, 397-436
4
0.92
3V5W
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-222, 224-264, 268-309
6
0.92
6CRK
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-181, 182-222, 224-264, 268-309
6
0.92
2BCJ
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-307
6
0.92
6OIK
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-181, 182-223, 224-264, 268-308
6
0.92
3DWL
C
P78774
Actin-related protein 2/3 complex subunit 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
54-82, 98-129, 144-184
3
0.92
5KDO
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-128, 141-181, 182-222, 224-264, 268-308
6
0.92
1GOT
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-309
6
0.92
6F1U
h
Q13409
Cytoplasmic dynein 1 intermediate chain 2
Homo sapiens (Human)
238-272, 291-326, 340-388, 391-439, 484-532
5
0.92
4QRJ
A
A7VAP0
Bacteroides uniformis (strain ATCC 8492 / DSM 6597 / CIP 103695 / JCM
113-152, 168-207, 217-252, 313-350
4
0.91
4QRJ
B
A7VAP0
Bacteroides uniformis (strain ATCC 8492 / DSM 6597 / CIP 103695 / JCM
113-152, 168-207, 217-252, 313-350
4
0.91
6ND4
U
P33750
Protein SOF1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
66-107, 178-216, 218-259, 261-301, 303-343, 347-386
6
0.91
4BL0
A
P26449
Cell cycle arrest protein BUB3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
21-57, 68-100, 111-148, 160-201, 261-295
5
0.91
6F3A
g
Q13409
Cytoplasmic dynein 1 intermediate chain 2
Homo sapiens (Human)
328-375, 379-426, 427-467, 479-519, 522-557
5
0.91
3UVK
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 257-298, 300-334
6
0.91
3SOV
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
93-133, 135-173, 180-220
3
0.91
3FVZ
A
P14925
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase {ECO:0000303|PubMed:10504734}
Rattus norvegicus (Rat)
579-617, 632-672, 684-720
3
0.91
2YMU
B
B2J0I0
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
14-54, 55-95, 96-135, 137-176, 179-218, 219-259, 260-299, 302-341, 342-382, 383-423, 425-464, 466-505, 506-546, 547-577
14
0.91
5YZV
A
P49695
Probable serine/threonine-protein kinase PkwA
Thermomonospora curvata
457-497, 499-530, 542-582, 583-623, 629-664, 667-707
6
0.91
5UKK
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 182-222, 224-264, 269-308
5
0.91
5A5U
I
P40217
Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
8-38, 50-91, 92-131
3
0.91
4MK0
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-309
6
0.91
5GAN
H
P20053
U4/U6 small nuclear ribonucleoprotein PRP4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
165-205, 208-249, 254-295, 339-379
4
0.91
3VH0
D
P76116
Uncharacterized protein YncE
Escherichia coli (strain K12)
88-128, 140-174, 185-223, 229-270, 271-311
5
0.90
2CE9
C
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
482-521, 529-571, 573-612, 614-655, 656-694, 696-737, 738-770
7
0.90
2H6K
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
44-84, 85-126, 127-168, 169-209, 223-253, 257-298
6
0.90
5IGQ
C
Q8NHY2
E3 ubiquitin-protein ligase COP1 {ECO:0000305}
Homo sapiens (Human)
424-457, 469-509, 512-553, 554-592
4
0.90
5UKL
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
57-94, 96-133, 141-180, 182-222, 224-264, 268-308
6
0.90
2CNX
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-210, 223-253, 257-297
6
0.90