Database of Structural Repeats in Proteins



Protein prenyltransferase alpha subunit - PFTA


Protein prenylation is the posttranslational attachment of either a farnesyl group or a geranylgeranyl group via a thioether linkage (-C-S-C-) to a cysteine at or near the carboxyl terminus of the protein. Farnesyl and geranylgeranyl groups are polyisoprenes, unsaturated hydrocarbons with a multiple of five carbons; the chain is 15 carbons long in the farnesyl moiety and 20 carbons long in the geranylgeranyl moiety. The alpha subunit is thought to participate in a stable complex with the isoprenyl substrate. In the alpha subunits of both types of protein prenyltransferases, seven tetratricopeptide repeats are formed by pairs of helices that are stabilised by conserved intercalating residues.

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InterPro:

IPR002088

PROSITE:

PS51147

Pfam:

PF01239

Number of PDB chains with PFTA repeat: 192
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
6IGL
A
P24530
Endothelin receptor type B {ECO:0000305}
Homo sapiens (Human)
1049-1078, 1079-1105, 1112-1140
3
0.68
6D84
B
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
24-57, 58-86, 201-230, 234-272, 273-312
5
0.83
6D84
F
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
24-57, 58-86, 201-230, 234-272, 273-312
5
0.83
6BUY
A
P15145
Aminopeptidase N {ECO:0000305}
Sus scrofa (Pig)
672-707, 803-834, 846-880, 893-919
4
0.72
6BCO
A
Q7TN37
Transient receptor potential cation channel subfamily M member 4
Mus musculus (Mouse)
247-273, 386-417, 422-448, 458-484
4
0.64
6BCO
B
Q7TN37
Transient receptor potential cation channel subfamily M member 4
Mus musculus (Mouse)
247-273, 386-417, 422-448, 458-484
4
0.64
6BCO
C
Q7TN37
Transient receptor potential cation channel subfamily M member 4
Mus musculus (Mouse)
247-273, 386-417, 422-448, 458-484
4
0.64
6BCO
D
Q7TN37
Transient receptor potential cation channel subfamily M member 4
Mus musculus (Mouse)
247-273, 386-417, 422-448, 458-484
4
0.64
5ZWO
N
P19735
Pre-mRNA-splicing factor 6
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
241-269, 275-304, 308-334, 393-423, 542-567, 753-785
6
0.62
5Y3R
C
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
281-303, 907-945, 1094-1133, 1581-1609, 1877-1911, 2427-2461, 2790-2825, 2912-2944, 2945-2975, 2986-3020, 3169-3199, 3227-3266, 4085-4112
13
0.76
5VHP
f
Q13200
26S proteasome non-ATPase regulatory subunit 2
Homo sapiens (Human)
72-100, 164-192, 259-287, 355-382, 606-635, 640-668, 669-699
7
0.66
5VHH
U
Q99460
26S proteasome non-ATPase regulatory subunit 1
Homo sapiens (Human)
41-73, 388-415, 526-558, 562-592, 597-626
5
0.65
5VGZ
X
O00231
26S proteasome non-ATPase regulatory subunit 11
Homo sapiens (Human)
39-79, 82-120, 123-160, 274-309
4
0.76
5V7V
A
Q05787
ERAD-associated E3 ubiquitin-protein ligase component HRD3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
399-435, 536-565, 570-608, 609-636, 640-671
5
0.75
5TUW
B
P74102
Red carotenoid-binding protein {ECO:0000303|PubMed:9398074}
Synechocystis sp
33-73, 89-119, 131-164
3
0.85
5T0G
f
Q13200
26S proteasome non-ATPase regulatory subunit 2
Homo sapiens (Human)
207-240, 280-312, 373-412, 414-440, 448-485
5
0.78
5T0C
Af
-
-
-
366-399, 439-471, 532-571, 573-599, 607-644
5
0.78
5T0C
Bf
-
-
-
366-399, 439-471, 532-571, 573-599, 607-644
5
0.78
5O9Z
G
O94906
Pre-mRNA-processing factor 6
Homo sapiens (Human)
325-355, 433-462, 540-569, 570-603, 604-637, 858-891
6
0.72
5NNR
D
G0S4M4
Chaetomium thermophilum (strain DSM 1495 / CBS 144
25-58, 175-214, 235-269, 272-299, 300-334
5
0.81
5LUQ
A
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
289-329, 758-782, 1145-1179, 1582-1609, 1797-1822, 1971-2002, 2207-2246, 2377-2407, 2866-2900, 2910-2944, 2945-2975, 2988-3018, 3031-3071, 3443-3474, 3614-3653
15
0.77
5LPH
A
O60308
Centrosomal protein of 104 kDa
Homo sapiens (Human)
471-515, 566-602, 607-638, 648-673
4
0.75
5LPH
B
O60308
Centrosomal protein of 104 kDa
Homo sapiens (Human)
471-515, 566-602, 606-640, 648-675
4
0.78
5KSX
F
P14324
Farnesyl pyrophosphate synthase
Homo sapiens (Human)
252-277, 278-308, 309-346
3
0.73
5K1V
A
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
638-675, 801-833, 834-867, 868-907
4
0.86
5K1V
B
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
638-675, 801-830, 834-867, 868-903
4
0.78
5J6S
B
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
764-786, 801-830, 834-867, 868-900
4
0.69
5HNA
D
A5K4U6
Plasmodium vivax (strain Salvador I)
292-321, 322-352, 354-394
3
0.73
5HN7
C
A5K4U6
Plasmodium vivax (strain Salvador I)
294-321, 322-352, 353-392
3
0.75
5HN7
F
A5K4U6
Plasmodium vivax (strain Salvador I)
294-321, 322-352, 353-391
3
0.75
5GJR
4
O00231
26S proteasome non-ATPase regulatory subunit 11
Homo sapiens (Human)
2-31, 39-80, 91-122, 242-270
4
0.68
5GJR
Q
O00231
26S proteasome non-ATPase regulatory subunit 11
Homo sapiens (Human)
2-31, 39-80, 91-122, 242-270
4
0.68
5G05
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
70-96, 150-184, 222-257, 262-296, 297-326
5
0.79
5G05
P
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
170-202, 227-261, 262-296, 297-326
4
0.85
5G05
X
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
73-110, 135-163, 164-198, 199-228, 232-267, 492-524
6
0.83
5G04
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
78-111, 150-184, 222-257, 258-292, 293-326, 413-439
6
0.82
5G04
X
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
135-163, 164-198, 199-228, 232-266, 287-320, 404-437, 438-471, 492-522
8
0.76
5FLC
A
-
-
-
511-543, 744-774, 782-816, 830-866
4
0.84
5FLC
E
-
-
-
511-543, 744-774, 782-816, 830-866
4
0.84
5CU5
A
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
801-830, 834-867, 868-907
3
0.82
5CU5
B
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
801-830, 834-867, 868-907
3
0.82
5BV1
D
G0S6M7
Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
532-557, 558-584, 714-741, 742-774, 776-803
5
0.73
5AHU
B
Q86C09
Trypanosoma brucei
264-291, 292-320, 322-361
3
0.72
5AHU
D
Q86C09
Trypanosoma brucei
264-291, 292-320, 322-361
3
0.73
5AFX
B
Q86C09
Trypanosoma brucei
264-289, 291-320, 322-367
3
0.67
5AEL
B
Q86C09
Trypanosoma brucei
264-289, 290-320, 322-367
3
0.72
5AB2
A
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
638-675, 801-830, 834-867, 868-907
4
0.82
5AB2
B
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
801-830, 834-867, 868-908
3
0.80
5AB0
A
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
801-830, 834-867, 879-907
3
0.80
5AB0
C
Q6P179
Endoplasmic reticulum aminopeptidase 2
Homo sapiens (Human)
677-712, 801-833, 834-867, 868-908
4
0.83