Database of Structural Repeats in Proteins



Protein prenyltransferase alpha subunit - PFTA


Protein prenylation is the posttranslational attachment of either a farnesyl group or a geranylgeranyl group via a thioether linkage (-C-S-C-) to a cysteine at or near the carboxyl terminus of the protein. Farnesyl and geranylgeranyl groups are polyisoprenes, unsaturated hydrocarbons with a multiple of five carbons; the chain is 15 carbons long in the farnesyl moiety and 20 carbons long in the geranylgeranyl moiety. The alpha subunit is thought to participate in a stable complex with the isoprenyl substrate. In the alpha subunits of both types of protein prenyltransferases, seven tetratricopeptide repeats are formed by pairs of helices that are stabilised by conserved intercalating residues.

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InterPro:

IPR002088

PROSITE:

PS51147

Pfam:

PF01239

Number of PDB chains with PFTA repeat: 192
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5LUQ
A
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
289-329, 758-782, 1145-1179, 1582-1609, 1797-1822, 1971-2002, 2207-2246, 2377-2407, 2866-2900, 2910-2944, 2945-2975, 2988-3018, 3031-3071, 3443-3474, 3614-3653
15
0.77
5Y3R
C
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
281-303, 907-945, 1094-1133, 1581-1609, 1877-1911, 2427-2461, 2790-2825, 2912-2944, 2945-2975, 2986-3020, 3169-3199, 3227-3266, 4085-4112
13
0.76
4M59
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
138-165, 202-238, 274-309, 379-414, 415-449, 450-483, 550-588, 625-657, 658-696, 697-728
10
0.82
4OE1
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
138-165, 202-238, 274-309, 379-414, 415-449, 450-483, 550-588, 625-657, 658-696, 697-728
10
0.82
4M57
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
69-98, 105-137, 138-166, 203-239, 344-379, 449-484, 612-637, 697-727, 729-763
9
0.78
5G04
X
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
135-163, 164-198, 199-228, 232-266, 287-320, 404-437, 438-471, 492-522
8
0.76
4KVM
D
O74985
N-terminal acetyltransferase A complex subunit nat1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
8-40, 109-141, 142-175, 180-217, 219-251, 306-337, 444-476, 655-690
8
0.74
4M59
B
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
106-136, 138-165, 203-239, 414-448, 449-483, 487-521, 661-696
7
0.79
5VHP
f
Q13200
26S proteasome non-ATPase regulatory subunit 2
Homo sapiens (Human)
72-100, 164-192, 259-287, 355-382, 606-635, 640-668, 669-699
7
0.66
4KVM
A
O74985
N-terminal acetyltransferase A complex subunit nat1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
109-141, 142-175, 180-217, 219-251, 306-337, 444-476, 655-690
7
0.74
4JT6
B
P42345
Serine/threonine-protein kinase mTOR
Homo sapiens (Human)
1446-1469, 1470-1499, 1500-1534, 1536-1577, 1694-1731, 1933-1969, 2263-2294
7
0.76
4OE1
B
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
106-136, 138-165, 203-239, 414-448, 449-483, 487-521, 661-696
7
0.79
1TNB
E
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
1TNB
K
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
1SA4
A
P49354
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Homo sapiens (Human)
112-146, 147-179, 181-215, 218-252, 253-287, 292-326
6
0.83
1TNY
E
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
1TNY
K
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
4UQI
B
P63010
AP-2 complex subunit beta
Homo sapiens (Human)
14-47, 234-272, 273-312, 317-346, 427-455, 470-498
6
0.81
3EU5
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 218-252, 253-288, 292-326
6
0.87
3S4W
B
Q80V62
Fanconi anemia group D2 protein homolog
Mus musculus (Mouse)
187-216, 221-249, 254-290, 502-545, 1000-1035, 1093-1122
6
0.73
1TNY
I
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
5O9Z
G
O94906
Pre-mRNA-processing factor 6
Homo sapiens (Human)
325-355, 433-462, 540-569, 570-603, 604-637, 858-891
6
0.72
5ZWO
N
P19735
Pre-mRNA-splicing factor 6
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
241-269, 275-304, 308-334, 393-423, 542-567, 753-785
6
0.62
1TNY
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249, 253-288
6
0.83
5G04
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
78-111, 150-184, 222-257, 258-292, 293-326, 413-439
6
0.82
5G05
X
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
73-110, 135-163, 164-198, 199-228, 232-267, 492-524
6
0.83
1MZC
A
P49354
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Homo sapiens (Human)
112-146, 147-179, 181-215, 218-252, 253-284
5
0.82
1N4P
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-181, 182-215, 216-249, 253-288
5
0.86
2ZIR
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 273-307
5
0.91
1KZP
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 218-252, 273-307
5
0.88
1KZO
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 273-307
5
0.88
2QUQ
A
P40969
Centromere DNA-binding protein complex CBF3 subunit B
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
82-120, 223-249, 387-422, 427-476, 480-523
5
0.82
1TNB
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 215-249, 253-287
5
0.78
1TNB
I
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
82-112, 114-146, 147-181, 182-215, 216-249
5
0.83
1TNO
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-181, 182-215, 218-252, 253-288
5
0.87
1TNO
C
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
114-146, 147-181, 182-215, 216-249, 253-288
5
0.86
1TNO
E
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 253-287
5
0.82
1FPP
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 273-307
5
0.91
2H6F
A
P49354
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Homo sapiens (Human)
112-146, 147-179, 181-215, 218-252, 253-284
5
0.82
1N4S
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-181, 182-215, 216-249, 253-288
5
0.86
3KSL
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-181, 182-215, 218-252, 274-307
5
0.88
2ZIS
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 273-307
5
0.91
1N4Q
E
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
114-146, 147-181, 182-215, 216-249, 253-288
5
0.81
1O1R
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 216-249, 273-307
5
0.90
2R2L
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 218-252, 274-307
5
0.87
1N9A
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 181-215, 218-252, 253-288, 292-325
5
0.84
2OOE
A
Q99LI7
Cleavage stimulation factor subunit 3
Mus musculus (Mouse)
20-44, 45-78, 79-110, 116-152, 369-403
5
0.76
1N4S
K
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 218-252, 253-288
5
0.82
1N4S
E
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
112-146, 147-179, 181-215, 218-252, 253-287
5
0.82
2VGL
B
P63010
AP-2 complex subunit beta
Homo sapiens (Human)
14-47, 317-346, 427-456, 461-497, 499-534
5
0.78