Database of Structural Repeats in Proteins



Low-density lipoprotein receptor repeat - LDL-Receptor


The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the innermost strand of each blade is labeled 1 and the outermost strand, 4. The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand 1 of the blade that harbors strands 24 from the first sequence repeat. The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells.

Link to other db

InterPro:

IPR000033

PROSITE:

PS51120

SMART:

SM00135

Pfam:

PF00058

Number of PDB chains with LDL-Receptor repeat: 147
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
1P22
A
Q9Y297
F-box/WD repeat-containing protein 1A
Homo sapiens (Human)
278-314, 318-354, 358-390
3
0.72
3V65
B
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-510, 523-555, 566-599, 610-642, 651-690
5
0.74
3V64
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-510, 523-562, 566-608, 650-691
4
0.82
3V65
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-512, 523-565, 566-608, 610-642, 651-684
5
0.79
3V64
C
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-512, 523-562, 566-608, 610-642, 651-690
5
0.80
6IGB
A
Q9HWH7
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / J
192-226, 243-275, 296-329, 344-378
4
0.68
6N31
A
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
155-187, 269-299, 309-342, 356-388
4
0.68
6N31
B
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
155-187, 269-306, 310-342, 356-395
4
0.70
6BLY
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
132-162, 215-249, 257-299, 301-332
4
0.72
6K1S
B
Q9BQA1
Methylosome protein 50
Homo sapiens (Human)
99-136, 138-169, 181-223
3
0.79
5V4B
B
Q969H0
F-box/WD repeat-containing protein 7 {ECO:0000305}
Homo sapiens (Human)
2392-2422, 2472-2509, 2512-2543, 2552-2583, 2642-2679
5
0.70
2OVP
B
Q969H0
F-box/WD repeat-containing protein 7 {ECO:0000305}
Homo sapiens (Human)
2432-2462, 2472-2509, 2512-2543, 2551-2585, 2593-2632, 2635-2667
6
0.72
4I79
B
Q8NFH3
Nucleoporin Nup43
Homo sapiens (Human)
86-120, 142-174, 184-215, 231-263
4
0.69
4ZLR
B
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-968
4
0.79
5EX7
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 882-916, 926-968, 970-1001
4
0.73
4ZLR
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-965, 969-1000
5
0.74
1Q7F
B
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 885-916, 926-965, 970-1003
5
0.71
1Q7F
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-968, 971-1003
5
0.77
3FGB
A
Q89ZH8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
246-277, 294-337, 341-375
3
0.74
3FGB
B
Q89ZH8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 1058
36-70, 246-277, 294-337, 341-375
4
0.72
2P9W
A
Q6WIF3
Malassezia sympodialis (Atopic eczema-associated yeast)
47-79, 170-202, 219-250, 268-298
4
0.68
5IT9
g
Q6CNI7
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
32-64, 79-116, 121-158
3
0.73
5IT7
g
Q6CNI7
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
32-63, 79-116, 121-154
3
0.72
4A08
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 506-536, 554-586, 599-636, 920-953
5
0.69
6DSZ
B
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 467-499, 505-536, 554-586
4
0.63
4A11
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 506-536, 554-586, 600-630, 920-953
6
0.63
6DSZ
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 465-499, 506-536, 554-586, 921-951
6
0.65
4TZ4
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
218-249, 424-454, 466-499, 505-535, 553-586, 878-912
6
0.63
6FCV
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
28-60, 467-497, 505-536, 554-586, 878-917, 920-953
6
0.66
4CI3
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 467-497, 506-536, 554-586
5
0.65
5B4X
D
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
291-321, 379-411, 422-464, 466-508, 509-543
5
0.78
5B4X
B
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
379-418, 422-462, 466-508, 509-543
4
0.83
1PEV
A
Q11176
Actin-interacting protein 1
Caenorhabditis elegans
72-114, 116-158, 253-295, 337-369, 380-422, 461-499, 504-538, 549-591
8
0.84
6G16
G
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.67
6G16
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-223, 241-273, 287-319
3
0.67
3GFC
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-223, 241-273, 287-319
3
0.69
4PC0
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
138-170, 191-224, 241-273, 287-319
4
0.68
6BW3
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-223, 241-273, 287-319
3
0.69
6G16
E
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.67
6G16
C
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.66
6EOJ
A
Q06632
Protein CFT1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
74-104, 1095-1136, 1137-1168, 1183-1219
4
0.73
2CE8
D
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
447-481, 497-528, 543-576
3
0.66
4XMM
A
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-63, 68-110, 114-156
3
0.90
2PM9
B
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-54, 68-101, 114-156
3
0.73
2PM7
B
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
113-156, 171-202, 219-251
3
0.72
2PM6
D
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-55, 68-101, 114-156
3
0.77
4BZJ
F
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-54, 68-101, 114-156
3
0.73
4BZK
F
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-54, 68-101, 114-156
3
0.73
3MZK
A
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-54, 68-102, 114-156
3
0.74
3MZK
D
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-54, 68-101, 114-156
3
0.74