Database of Structural Repeats in Proteins



Low-density lipoprotein receptor repeat - LDL-Receptor


The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the innermost strand of each blade is labeled 1 and the outermost strand, 4. The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand 1 of the blade that harbors strands 24 from the first sequence repeat. The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells.

Link to other db

InterPro:

IPR000033

PROSITE:

PS51120

SMART:

SM00135

Pfam:

PF00058

Number of PDB chains with LDL-Receptor repeat: 147
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
4XMN
A
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-63, 68-110, 114-156
3
0.91
4XMM
A
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-63, 68-110, 114-156
3
0.90
3BG0
E
P55735
Protein SEC13 homolog {ECO:0000305}
Homo sapiens (Human)
72-114, 118-160, 181-223
3
0.89
3BG0
A
P55735
Protein SEC13 homolog {ECO:0000305}
Homo sapiens (Human)
72-114, 118-160, 181-223
3
0.89
3WW9
A
-
-
-
24-62, 66-108, 109-150, 151-188, 192-230
5
0.85
3S94
B
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
371-412, 414-455, 510-543, 551-582
4
0.85
3JRP
A
Q04491
Protein transport protein SEC13
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-55, 68-109, 114-156
3
0.85
1LPX
A
P98157
Low-density lipoprotein receptor-related protein 1
Gallus gallus (Chicken)
3066-3100, 3111-3149, 3154-3196, 3198-3239, 3240-3271
5
0.85
1PEV
A
Q11176
Actin-interacting protein 1
Caenorhabditis elegans
72-114, 116-158, 253-295, 337-369, 380-422, 461-499, 504-538, 549-591
8
0.84
4ZOX
A
P35184
Ribosome assembly protein SQT1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
78-120, 122-164, 168-203
3
0.83
2Z2O
C
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-152, 153-194, 195-236, 237-274
6
0.83
2Z2O
B
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-64, 68-99, 110-152, 153-194, 195-235, 236-274
6
0.83
1NDX
A
P14543
Nidogen-1
Homo sapiens (Human)
1033-1075, 1083-1120, 1121-1157, 1168-1204
4
0.83
5B4X
B
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
379-418, 422-462, 466-508, 509-543
4
0.83
3SOB
B
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-59, 64-96, 107-146, 150-192, 194-233, 235-278
6
0.83
1RWI
B
P9WI79
Serine/threonine-protein kinase PknD
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
119-157, 161-193, 202-244
3
0.83
1NPE
A
P10493
Nidogen-1
Mus musculus (Mouse)
960-1002, 1003-1035, 1047-1089, 1091-1129, 1138-1174
5
0.83
3V64
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-510, 523-562, 566-608, 650-691
4
0.82
3SOQ
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-52, 63-96, 107-146, 150-192, 194-233, 235-278
6
0.82
3S94
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
107-139, 150-192, 235-274, 329-361, 372-414, 415-447, 459-491, 503-543
8
0.81
3SOV
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-59, 64-96, 107-146, 150-192, 194-233, 235-278
6
0.81
1LRX
B
P01130
Low-density lipoprotein receptor
Homo sapiens (Human)
439-471, 486-524, 529-571, 573-604, 616-658
5
0.81
6F0S
A
-
-
-
24-62, 66-104, 107-149, 150-188, 192-224
5
0.81
5JCS
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
5FL8
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
1RI6
A
P52697
6-phosphogluconolactonase
Escherichia coli (strain K12)
4-37, 50-85, 96-138, 290-333
4
0.80
3V64
C
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-512, 523-562, 566-608, 610-642, 651-690
5
0.80
2Z2P
B
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-142, 152-194, 195-235, 236-274
6
0.80
2Z2P
A
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-142, 152-194, 195-235, 236-274
6
0.80
6F0Q
B
-
-
-
24-62, 66-104, 108-146, 150-188, 192-230
5
0.80
6NAU
A
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 189-221, 242-284, 288-330
7
0.80
6NAU
C
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 188-220, 242-284, 288-330
7
0.80
5I2T
A
P25635
Periodic tryptophan protein 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
68-104, 400-432, 442-484, 488-528
4
0.80
1RWL
A
P9WI79
Serine/threonine-protein kinase PknD
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
119-157, 161-199, 203-241
3
0.80
1RWI
A
P9WI79
Serine/threonine-protein kinase PknD
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
119-157, 161-199, 203-241
3
0.80
4ZLR
B
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-968
4
0.79
3WWA
A
-
-
-
24-56, 66-104, 108-146, 150-188, 192-224
5
0.79
6F0Q
A
-
-
-
24-62, 66-104, 108-142, 150-184, 192-230
5
0.79
6K1S
B
Q9BQA1
Methylosome protein 50
Homo sapiens (Human)
99-136, 138-169, 181-223
3
0.79
6M8S
G
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
68-105, 197-235, 239-281, 283-320
4
0.79
3V65
D
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-512, 523-565, 566-608, 610-642, 651-684
5
0.79
6NAU
B
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
3-46, 48-84, 94-136, 139-171, 188-220, 242-284, 288-321
7
0.79
6F0T
A
-
-
-
24-62, 66-98, 108-146, 150-188, 192-230
5
0.78
6F0T
C
-
-
-
24-62, 66-104, 108-146, 150-182, 192-226
5
0.78
4BTS
BR
-
-
-
40-72, 89-127, 131-173
3
0.78
3FM0
A
O76071
Probable cytosolic iron-sulfur protein assembly protein CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037}
Homo sapiens (Human)
29-61, 74-107, 125-161, 163-205
4
0.78
4BTS
CR
-
-
-
40-72, 89-127, 131-173
3
0.78
3M0C
C
P01130
Low-density lipoprotein receptor
Homo sapiens (Human)
465-497, 508-551, 553-593, 595-629
4
0.78
4WJS
A
G0SC29
Ribosome assembly protein 4 {ECO:0000250|UniProtKB:P25382}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
202-234, 251-282, 292-323, 373-415, 459-496
5
0.78
1IJQ
B
P01130
Low-density lipoprotein receptor
Homo sapiens (Human)
465-497, 508-551, 553-593, 595-629
4
0.78