Database of Structural Repeats in Proteins



Low-density lipoprotein receptor repeat - LDL-Receptor


The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the innermost strand of each blade is labeled 1 and the outermost strand, 4. The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand 1 of the blade that harbors strands 24 from the first sequence repeat. The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells.

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InterPro:

IPR000033

PROSITE:

PS51120

SMART:

SM00135

Pfam:

PF00058

Number of PDB chains with LDL-Receptor repeat: 147
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
6RTE
B
A0A0C7D2F2
Pseudomonas aeruginosa
198-229, 246-277, 289-323, 335-366, 379-414
5
0.66
6RTD
A
A0A0C7D2F2
Pseudomonas aeruginosa
247-279, 290-322, 335-366
3
0.67
6RTD
B
A0A0C7D2F2
Pseudomonas aeruginosa
115-147, 246-277, 290-323, 335-365
4
0.65
6NBI
B
P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Rattus norvegicus (Rat)
68-105, 110-145, 155-185, 197-227, 239-281, 284-314
6
0.70
6NAU
A
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 189-221, 242-284, 288-330
7
0.80
6NAU
B
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
3-46, 48-84, 94-136, 139-171, 188-220, 242-284, 288-321
7
0.79
6NAU
C
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 188-220, 242-284, 288-330
7
0.80
6N4B
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
68-105, 111-153, 197-227, 239-281, 283-313
5
0.76
6N31
A
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
155-187, 269-299, 309-342, 356-388
4
0.68
6N31
B
Q9GZL7
Ribosome biogenesis protein WDR12 {ECO:0000255|HAMAP-Rule:MF_03029}
Homo sapiens (Human)
155-187, 269-306, 310-342, 356-395
4
0.70
6M8S
G
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
68-105, 197-235, 239-281, 283-320
4
0.79
6K1S
B
Q9BQA1
Methylosome protein 50
Homo sapiens (Human)
99-136, 138-169, 181-223
3
0.79
6IGB
A
Q9HWH7
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / J
192-226, 243-275, 296-329, 344-378
4
0.68
6ID0
W
O60508
Pre-mRNA-processing factor 17
Homo sapiens (Human)
302-334, 389-420, 431-464, 475-508, 521-552
5
0.70
6G16
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-223, 241-273, 287-319
3
0.67
6G16
C
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.66
6G16
E
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.67
6G16
G
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-224, 241-273, 287-319
3
0.67
6FHY
B
C7BLE4
Photorhabdus asymbiotica subsp
91-123, 234-266, 282-314, 331-361
4
0.61
6FCV
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
28-60, 467-497, 505-536, 554-586, 878-917, 920-953
6
0.66
6F0T
A
-
-
-
24-62, 66-98, 108-146, 150-188, 192-230
5
0.78
6F0T
B
-
-
-
24-62, 66-104, 108-146, 150-182, 192-224
5
0.77
6F0T
C
-
-
-
24-62, 66-104, 108-146, 150-182, 192-226
5
0.78
6F0S
A
-
-
-
24-62, 66-104, 107-149, 150-188, 192-224
5
0.81
6F0Q
A
-
-
-
24-62, 66-104, 108-142, 150-184, 192-230
5
0.79
6F0Q
B
-
-
-
24-62, 66-104, 108-146, 150-188, 192-230
5
0.80
6EOJ
A
Q06632
Protein CFT1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
74-104, 1095-1136, 1137-1168, 1183-1219
4
0.73
6E3Y
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
68-99, 110-141, 197-227, 239-281, 283-320
5
0.75
6DSZ
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 465-499, 506-536, 554-586, 921-951
6
0.65
6DSZ
B
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 467-499, 505-536, 554-586
4
0.63
6DDF
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
110-145, 197-234, 246-278, 283-314
4
0.71
6D9H
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
69-105, 110-146, 155-185, 197-227, 239-281, 283-313
6
0.70
6BW3
A
Q09028
Histone-binding protein RBBP4
Homo sapiens (Human)
191-223, 241-273, 287-319
3
0.69
6BLY
B
Q9C0J8
pre-mRNA 3' end processing protein WDR33
Homo sapiens (Human)
132-162, 215-249, 257-299, 301-332
4
0.72
6AH0
K
O43172
U4/U6 small nuclear ribonucleoprotein Prp4
Homo sapiens (Human)
336-367, 378-415, 420-453, 463-496
4
0.71
5VH9
B
P39946
Nuclear distribution protein PAC1 {ECO:0000255|HAMAP-Rule:MF_03141}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
168-205, 221-253, 268-306, 308-345
4
0.73
5V4B
B
Q969H0
F-box/WD repeat-containing protein 7 {ECO:0000305}
Homo sapiens (Human)
2392-2422, 2472-2509, 2512-2543, 2552-2583, 2642-2679
5
0.70
5TZS
R
-
-
-
72-102, 337-369, 461-499, 504-538, 549-581
5
0.72
5M2N
A
P42935
Elongator complex protein 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
71-103, 115-146, 165-199, 718-751
4
0.66
5JCS
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
5IT9
g
Q6CNI7
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
32-64, 79-116, 121-158
3
0.73
5IT7
g
Q6CNI7
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
32-63, 79-116, 121-154
3
0.72
5I2T
A
P25635
Periodic tryptophan protein 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
68-104, 400-432, 442-484, 488-528
4
0.80
5GJE
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
2-40, 44-86, 88-120, 132-164, 175-208, 215-249, 353-395, 396-427, 440-472
9
0.76
5FWW
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
674-704, 717-756, 760-792, 802-841, 843-882, 1114-1145, 1154-1187
7
0.73
5FL8
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
5EX7
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 882-916, 926-968, 970-1001
4
0.73
5B4X
B
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
379-418, 422-462, 466-508, 509-543
4
0.83
5B4X
D
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
291-321, 379-411, 422-464, 466-508, 509-543
5
0.78
5A9Q
F
P55735
Protein SEC13 homolog {ECO:0000305}
Homo sapiens (Human)
72-106, 118-160, 180-212
3
0.75