Database of Structural Repeats in Proteins



Low-density lipoprotein receptor repeat - LDL-Receptor


The six YWTD repeats together fold into a six-bladed beta-propeller. Each blade of the propeller consists of four antiparallel beta-strands; the innermost strand of each blade is labeled 1 and the outermost strand, 4. The sequence repeats are offset with respect to the blades of the propeller, such that any given 40-residue YWTD repeat spans strands 24 of one propeller blade and strand 1 of the subsequent blade. This offset ensures circularization of the propeller because the last strand of the final sequence repeat acts as an innermost strand 1 of the blade that harbors strands 24 from the first sequence repeat. The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells.

Link to other db

InterPro:

IPR000033

PROSITE:

PS51120

SMART:

SM00135

Pfam:

PF00058

Number of PDB chains with LDL-Receptor repeat: 147
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
4DG6
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
2-40, 44-86, 88-120, 132-164, 175-208, 215-249, 353-395, 396-427, 440-472
9
0.76
5GJE
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
2-40, 44-86, 88-120, 132-164, 175-208, 215-249, 353-395, 396-427, 440-472
9
0.76
3S94
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
107-139, 150-192, 235-274, 329-361, 372-414, 415-447, 459-491, 503-543
8
0.81
1PEV
A
Q11176
Actin-interacting protein 1
Caenorhabditis elegans
72-114, 116-158, 253-295, 337-369, 380-422, 461-499, 504-538, 549-591
8
0.84
6NAU
B
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
3-46, 48-84, 94-136, 139-171, 188-220, 242-284, 288-321
7
0.79
6NAU
A
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 189-221, 242-284, 288-330
7
0.80
3S8Z
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
632-662, 674-704, 717-749, 802-840, 843-875, 1114-1155, 1156-1187
7
0.72
5JCS
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
6NAU
C
A6T6J6
6-phosphogluconolactonase {ECO:0000255|HAMAP-Rule:MF_01605}
Klebsiella pneumoniae subsp
10-46, 48-83, 94-136, 139-171, 188-220, 242-284, 288-330
7
0.80
5FWW
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
674-704, 717-756, 760-792, 802-841, 843-882, 1114-1145, 1154-1187
7
0.73
5FL8
q
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-188, 199-237, 249-287, 290-328, 372-414, 415-457, 458-494
7
0.81
4A11
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 506-536, 554-586, 600-630, 920-953
6
0.63
6D9H
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
69-105, 110-146, 155-185, 197-227, 239-281, 283-313
6
0.70
6DSZ
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 465-499, 506-536, 554-586, 921-951
6
0.65
2Z2P
B
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-142, 152-194, 195-235, 236-274
6
0.80
2Z2P
A
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-142, 152-194, 195-235, 236-274
6
0.80
2Z2O
C
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-58, 68-99, 110-152, 153-194, 195-236, 237-274
6
0.83
2Z2O
B
P17978
Virginiamycin B lyase
Staphylococcus aureus
26-64, 68-99, 110-152, 153-194, 195-235, 236-274
6
0.83
2Z2N
A
P17978
Virginiamycin B lyase
Staphylococcus aureus
25-61, 68-99, 109-141, 152-194, 195-235, 237-270
6
0.77
3SOV
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-59, 64-96, 107-146, 150-192, 194-233, 235-278
6
0.81
4WJV
A
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-187, 199-230, 290-328, 372-414, 415-446, 457-488
6
0.74
4TZ4
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
218-249, 424-454, 466-499, 505-535, 553-586, 878-912
6
0.63
6FCV
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
28-60, 467-497, 505-536, 554-586, 878-917, 920-953
6
0.66
6NBI
B
P54311
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Rattus norvegicus (Rat)
68-105, 110-145, 155-185, 197-227, 239-281, 284-314
6
0.70
3SOB
B
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-59, 64-96, 107-146, 150-192, 194-233, 235-278
6
0.83
3SOQ
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
21-52, 63-96, 107-146, 150-192, 194-233, 235-278
6
0.82
2OVP
B
Q969H0
F-box/WD repeat-containing protein 7 {ECO:0000305}
Homo sapiens (Human)
2432-2462, 2472-2509, 2512-2543, 2551-2585, 2593-2632, 2635-2667
6
0.72
4WJS
A
G0SC29
Ribosome assembly protein 4 {ECO:0000250|UniProtKB:P25382}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
202-234, 251-282, 292-323, 373-415, 459-496
5
0.78
4ZLR
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-965, 969-1000
5
0.74
3WWA
A
-
-
-
24-56, 66-104, 108-146, 150-188, 192-224
5
0.79
3MKQ
E
A6ZU46
Coatomer subunit beta' {ECO:0000256|PIRNR:PIRNR005567}
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
26-56, 110-148, 154-192, 199-236, 368-400
5
0.71
3V64
C
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-512, 523-562, 566-608, 610-642, 651-690
5
0.80
6F0Q
A
-
-
-
24-62, 66-104, 108-142, 150-184, 192-230
5
0.79
1JOF
B
P38677
Carboxy-cis,cis-muconate cyclase
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708
2-36, 107-140, 158-188, 205-240, 322-354
5
0.64
5TZS
R
-
-
-
72-102, 337-369, 461-499, 504-538, 549-581
5
0.72
3V65
B
Q9QYP1
Low-density lipoprotein receptor-related protein 4
Rattus norvegicus (Rat)
480-510, 523-555, 566-599, 610-642, 651-690
5
0.74
3F3P
F
P53011
Nucleoporin SEH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22-57, 70-104, 123-156, 181-213, 316-349
5
0.68
1NPE
A
P10493
Nidogen-1
Mus musculus (Mouse)
960-1002, 1003-1035, 1047-1089, 1091-1129, 1138-1174
5
0.83
4CI3
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
29-60, 422-454, 467-497, 506-536, 554-586
5
0.65
1Q7F
A
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 883-925, 926-968, 971-1003
5
0.77
1Q7F
B
Q8MQJ9
Brain tumor protein
Drosophila melanogaster (Fruit fly)
792-823, 840-872, 885-916, 926-965, 970-1003
5
0.71
4YCZ
A
G2QEZ2
Nup96 domain-containing protein {ECO:0000259|Pfam:PF12110}
Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799)
31-64, 77-119, 123-155, 183-214, 232-262
5
0.75
3WW9
A
-
-
-
24-62, 66-108, 109-150, 151-188, 192-230
5
0.85
5B4X
D
Q14114
Low-density lipoprotein receptor-related protein 8
Homo sapiens (Human)
291-321, 379-411, 422-464, 466-508, 509-543
5
0.78
5V4B
B
Q969H0
F-box/WD repeat-containing protein 7 {ECO:0000305}
Homo sapiens (Human)
2392-2422, 2472-2509, 2512-2543, 2552-2583, 2642-2679
5
0.70
6E3Y
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
68-99, 110-141, 197-227, 239-281, 283-320
5
0.75
2I3T
C
P26449
Cell cycle arrest protein BUB3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
24-66, 70-103, 114-145, 161-193, 264-302
5
0.74
2I3T
E
P26449
Cell cycle arrest protein BUB3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
24-66, 70-103, 114-145, 161-193, 264-302
5
0.74
2I3T
G
P26449
Cell cycle arrest protein BUB3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
24-66, 70-103, 114-145, 161-193, 264-302
5
0.74
4WJV
C
P25382
Ribosome assembly protein 4 {ECO:0000303|PubMed:16221974}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
157-187, 291-328, 372-404, 415-446, 457-494
5
0.71