Database of Structural Repeats in Proteins



HEAT repeat - HEAT


The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes. The HEAT repeats consist of pairs of antiparallel alpha helices.

Link to other db

InterPro:

IPR000357

Pfam:

PF02985

Number of PDB chains with HEAT repeat: 1114
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
4C0O
A
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 81-124, 125-154, 223-255, 258-285, 286-314, 633-677, 738-769, 770-808
9
0.76
6GX9
A
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
42-79, 88-124, 180-211, 224-255, 275-313, 356-387, 633-677, 738-769, 770-808, 809-844
10
0.76
4C0O
B
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 80-124, 156-189, 223-258, 259-285, 286-313, 537-570, 633-677, 738-769, 770-808
10
0.80
4C0Q
A
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 79-121, 122-154, 216-258, 266-312, 414-453, 454-494, 495-530, 531-573, 634-671, 717-763, 764-806, 814-864
13
0.84
4C0P
C
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 81-124, 125-154, 223-258, 259-285, 286-313, 535-570, 633-679, 680-716, 738-769, 771-809, 810-844
12
0.76
4C0P
B
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 81-124, 125-154, 223-258, 259-285, 286-314, 537-570, 633-679, 680-716, 738-769, 771-809, 810-844
12
0.76
4FZD
A
Q9Y376
Calcium-binding protein 39
Homo sapiens (Human)
77-111, 123-162, 163-195, 251-288
4
0.89
3EBB
D
Q9Y263
Phospholipase A-2-activating protein
Homo sapiens (Human)
562-590, 591-621, 635-667, 721-766, 767-795
5
0.65
3C2H
B
Q9XVI2
Caenorhabditis elegans
180-217, 225-267, 453-493, 494-535, 547-590, 615-653, 725-759, 760-796
8
0.82
3C2G
A
Q9XVI2
Caenorhabditis elegans
181-219, 344-377, 403-451, 453-493, 494-535, 547-588, 673-716, 717-759, 760-796
9
0.82
3C2G
B
Q9XVI2
Caenorhabditis elegans
181-219, 227-268, 344-377, 403-451, 453-493, 494-535, 547-588, 717-759, 760-794
9
0.80
6DMR
C
Q9XSM3
Transient receptor potential cation channel subfamily V member 5
Oryctolagus cuniculus (Rabbit)
29-67, 68-101, 102-139, 569-613
4
0.88
6DMR
A
Q9XSM3
Transient receptor potential cation channel subfamily V member 5
Oryctolagus cuniculus (Rabbit)
29-67, 68-101, 102-139, 569-613
4
0.88
6DMR
D
Q9XSM3
Transient receptor potential cation channel subfamily V member 5
Oryctolagus cuniculus (Rabbit)
29-67, 68-101, 102-139, 569-613
4
0.88
6DMR
B
Q9XSM3
Transient receptor potential cation channel subfamily V member 5
Oryctolagus cuniculus (Rabbit)
29-67, 68-101, 102-139, 569-613
4
0.88
4ARE
A
Q9X721
Collagenase ColG {ECO:0000303|PubMed:9922257}
Hathewaya histolytica (Clostridium histolyticum)
159-202, 217-255, 256-301, 353-390
4
0.87
2Y6I
A
Q9X721
Collagenase ColG {ECO:0000303|PubMed:9922257}
Hathewaya histolytica (Clostridium histolyticum)
117-146, 161-204, 218-254, 256-303, 355-393
5
0.82
2Y3U
A
Q9X721
Collagenase ColG {ECO:0000303|PubMed:9922257}
Hathewaya histolytica (Clostridium histolyticum)
160-202, 212-255, 256-301
3
0.91
2X6H
B
Q9W1M7
Phosphatidylinositol 3-kinase catalytic subunit type 3 {ECO:0000256|PIRNR:PIRNR000587}
Drosophila melanogaster (Fruit fly)
376-405, 532-559, 569-620, 624-651, 770-804, 840-884
6
0.73
4Y5J
A
Q9VEZ3
Protein mini spindles
Drosophila melanogaster (Fruit fly)
592-627, 630-666, 707-745, 746-781, 782-816
5
0.80
2X1G
G
Q9VEC5
Drosophila melanogaster (Fruit fly)
77-116, 454-490, 501-538, 543-575, 685-726, 825-863, 864-908, 922-964
8
0.79
2X1G
F
Q9VEC5
Drosophila melanogaster (Fruit fly)
77-116, 454-490, 501-538, 543-575, 685-726, 825-863, 864-908, 922-964
8
0.79
3ZKV
A
Q9VEC5
Drosophila melanogaster (Fruit fly)
162-198, 281-327, 370-421, 497-539, 540-575, 576-618, 621-670, 684-727, 768-817, 818-861, 864-908
11
0.85
5VGZ
a
Q9UNM6
26S proteasome non-ATPase regulatory subunit 13
Homo sapiens (Human)
13-52, 53-87, 88-127
3
0.79
5VHF
a
Q9UNM6
26S proteasome non-ATPase regulatory subunit 13
Homo sapiens (Human)
3-31, 32-71, 88-125
3
0.75
5G04
O
Q9UJX4
Anaphase-promoting complex subunit 5
Homo sapiens (Human)
32-69, 105-145, 335-373, 392-432, 555-595, 596-636, 637-677
7
0.81
5G04
X
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
67-109, 150-184, 229-266, 285-318, 319-354
5
0.85
5G04
Y
Q9UJX3
Anaphase-promoting complex subunit 7
Homo sapiens (Human)
36-68, 73-110, 230-268, 287-318, 319-354, 438-471
6
0.72
5A31
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
29-61, 76-111, 183-221, 223-259, 260-292, 313-346
6
0.72
4UI9
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
29-61, 76-111, 183-221, 223-259, 260-292, 313-346
6
0.72
5G04
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
27-61, 150-184, 242-278, 279-312, 313-346
5
0.78
5G05
C
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
29-61, 97-136, 183-221, 223-259, 260-292, 313-346
6
0.74
5G05
P
Q9UJX2
Cell division cycle protein 23 homolog
Homo sapiens (Human)
29-63, 97-134, 165-202, 224-262, 263-292, 311-346
6
0.76
4PJ6
B
Q9UIQ6
Leucyl-cystinyl aminopeptidase, pregnancy serum form
Homo sapiens (Human)
383-414, 443-470, 471-505, 506-529, 871-915
5
0.71
5C97
A
Q9UIQ6
Leucyl-cystinyl aminopeptidase, pregnancy serum form
Homo sapiens (Human)
440-471, 759-805, 871-898, 903-934, 935-976
5
0.72
4P8Q
B
Q9UIQ6
Leucyl-cystinyl aminopeptidase, pregnancy serum form
Homo sapiens (Human)
785-813, 903-936, 937-975, 977-1022
4
0.70
3BXJ
A
Q9QUH6
Ras/Rap GTPase-activating protein SynGAP
Rattus norvegicus (Rat)
412-445, 468-504, 509-545, 548-582
4
0.65
5NH9
C
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
56-94, 107-136, 149-181
3
0.64
5NH9
B
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.64
5NH6
D
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.65
5NHC
D
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.65
5NHC
B
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.64
5NH4
B
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.63
5NH7
D
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
56-94, 107-136, 149-181
3
0.63
5NHD
A
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.63
5NHC
C
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.63
5NH9
D
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.65
5NH8
C
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.65
5NH8
B
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
56-94, 107-136, 149-181
3
0.63
5NHE
B
Q9P8C9
Xylose isomerase {ECO:0000256|RuleBase:RU000609}
Piromyces sp
59-94, 107-136, 149-181
3
0.65