Database of Structural Repeats in Proteins



HEAT repeat - HEAT


The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes. The HEAT repeats consist of pairs of antiparallel alpha helices.

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InterPro:

IPR000357

Pfam:

PF02985

Number of PDB chains with HEAT repeat: 1114
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
6RK9
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.90
6RK9
B
P00742
Activated factor Xa heavy chain
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.88
6Q84
A
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
36-69, 216-244, 286-313, 345-385, 414-447, 483-512, 524-562, 563-594, 595-622, 642-677, 800-842, 848-886, 889-935, 938-976, 977-1009, 1045-1073
16
0.79
6Q84
D
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
211-244, 273-313, 676-718, 797-836, 840-883, 889-929, 936-974
7
0.79
6Q83
A
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
37-67, 414-447, 486-522, 535-559, 560-594, 595-622, 849-888, 889-928, 937-975, 977-1009
10
0.79
6Q82
A
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
34-67, 80-129, 225-261, 273-312, 397-444, 575-622, 643-680, 674-718, 796-835, 839-883, 889-928, 937-973, 977-1023
13
0.77
6O7X
P
P41807
V-type proton ATPase subunit H
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
74-105, 120-157, 167-196, 197-228, 257-298, 393-435, 445-478
7
0.78
6O7W
P
P41807
V-type proton ATPase subunit H
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
23-55, 73-105, 120-157, 167-195, 197-232, 257-298, 299-332, 393-435, 445-478
9
0.77
6O7V
P
P41807
V-type proton ATPase subunit H
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
23-55, 73-110, 120-157, 167-196, 197-232, 237-280, 393-436, 445-478
8
0.87
6O07
A
G2WCC0
Saccharomyces cerevisiae (strain Kyokai no
309-354, 359-399, 414-449
3
0.89
6NPW
A
Q8MSU4
Symplekin {ECO:0000312|EMBL:AAF51962.2}
Drosophila melanogaster (Fruit fly)
21-58, 59-112, 140-170, 198-235
4
0.90
6NOD
C
Q09487
Caenorhabditis elegans
185-223, 224-257, 258-293, 294-329, 368-404, 405-440, 483-517
7
0.86
6NOC
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
256-298, 335-373, 383-424, 425-464, 465-514
5
0.88
6N1Z
A
Q96P70
Importin-9
Homo sapiens (Human)
55-96, 103-143, 146-181, 182-228, 346-380, 511-551, 555-594, 595-636, 687-730, 739-778, 779-816, 835-873
12
0.86
6N1Z
D
Q96P70
Importin-9
Homo sapiens (Human)
37-65, 66-96, 103-143, 144-181, 473-510, 511-551, 555-594, 595-636, 687-723, 739-778, 779-816, 835-873
12
0.83
6MZE
Z
A0A493R6X7
Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1
14-43, 86-113, 132-170, 175-213, 309-347, 432-470
6
0.82
6MFV
A
O58663
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR
391-431, 478-517, 518-557, 572-613
4
0.85
6MFV
B
O58663
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR
393-429, 480-517, 518-557, 558-595, 596-637
5
0.80
6MFV
C
O58663
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR
389-429, 480-517, 518-554, 555-597, 598-637
5
0.86
6M9M
A
A0A0M3KL00
Streptococcus mutans
34-67, 68-103, 104-137, 141-185
4
0.89
6IGX
B
Q9BPX3
Condensin complex subunit 3
Homo sapiens (Human)
95-130, 137-175, 176-207, 208-242, 243-277, 579-615, 616-654
7
0.85
6IGX
D
Q9BPX3
Condensin complex subunit 3
Homo sapiens (Human)
41-77, 95-134, 137-172, 243-280, 579-615, 616-654, 841-877
7
0.83
6IGL
A
P24530
Endothelin receptor type B {ECO:0000305}
Homo sapiens (Human)
91-129, 1082-1111, 311-349, 356-390
4
0.78
6IDX
A
Q96JJ3
Engulfment and cell motility protein 2
Homo sapiens (Human)
80-122, 125-167, 170-203, 214-249
4
0.79
6ICZ
V
Q9HCG8
Pre-mRNA-splicing factor CWC22 homolog
Homo sapiens (Human)
149-187, 192-226, 227-266, 271-308
4
0.77
6HON
A
Q92600
CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}
Homo sapiens (Human)
15-50, 106-149, 151-192, 202-242
4
0.81
6HON
C
Q92600
CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}
Homo sapiens (Human)
15-50, 62-102, 106-151, 152-192, 203-242
5
0.83
6HOM
A
Q92600
CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}
Homo sapiens (Human)
14-57, 115-149, 161-192, 203-250, 252-285
5
0.78
6HOM
C
Q92600
CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}
Homo sapiens (Human)
15-50, 62-102, 106-151, 152-192, 203-242, 251-284
6
0.80
6HD5
t
P12945
N-terminal acetyltransferase A complex subunit NAT1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
17-52, 190-219, 317-353, 380-413, 414-451, 452-477, 559-598
7
0.80
6HC2
A
P81274
G-protein-signaling modulator 2
Homo sapiens (Human)
13-50, 51-90, 153-191, 225-252, 263-293, 306-336
6
0.75
6HB3
A
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-41, 59-88, 90-129, 207-241, 323-357
5
0.81
6HB3
B
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-41, 59-88, 90-129, 207-241, 323-358
5
0.82
6HB3
C
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-41, 59-88, 90-129, 207-241, 323-356
5
0.81
6HB3
D
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-41, 56-88, 90-129, 206-241, 323-357
5
0.87
6HB2
C
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
2-35, 36-76, 89-120, 153-197
4
0.75
6HB1
A
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
5-32, 45-88, 90-129, 325-358
4
0.76
6HB1
C
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-41, 42-76, 89-129, 207-241, 324-356
5
0.79
6HB1
D
P48362
Protein HGH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
1-30, 45-88, 90-129, 207-241, 324-357
5
0.78
6GX9
A
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
42-79, 88-124, 180-211, 224-255, 275-313, 356-387, 633-677, 738-769, 770-808, 809-844
10
0.76
6GWD
I
-
-
-
13-41, 42-74, 75-105, 106-136
4
0.88
6GWC
C
-
-
-
11-54, 73-105, 106-136, 137-177
4
0.88
6GMH
Q
Q6PD62
RNA polymerase-associated protein CTR9 homolog
Homo sapiens (Human)
125-162, 179-210, 214-249, 285-321, 617-646
5
0.68
6G90
O
P49955
U2 snRNP component HSH155
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
215-255, 274-310, 311-364, 386-427, 428-470, 513-551, 552-593, 594-634, 635-674, 678-720, 721-758, 759-793, 794-828, 829-871, 872-911
15
0.87
6G7E
B
G0S6C0
Chaetomium thermophilum (strain DSM 1495 / CBS 144
2-34, 132-170, 312-351, 438-464, 465-502, 505-534, 559-598, 768-810, 901-953, 1135-1172, 1174-1210, 1212-1251
12
0.81
6G70
B
Q8K2Z2
Pre-mRNA-processing factor 39
Mus musculus (Mouse)
76-106, 297-338, 385-417, 418-451, 469-506
5
0.71
6FF7
u
O75533
Splicing factor 3B subunit 1
Homo sapiens (Human)
1069-1100, 1104-1138, 1141-1178, 1180-1218, 1223-1257
5
0.89
6FF4
u
O75533
Splicing factor 3B subunit 1
Homo sapiens (Human)
656-697, 698-738, 778-819, 821-861, 862-902, 904-945, 983-1024, 1025-1063, 1067-1108, 1141-1181, 1182-1221, 1223-1258
12
0.89
6FDW
A
Q8WQX9
Phosphodiesterase {ECO:0000256|RuleBase:RU363067}
Trypanosoma brucei
760-800, 801-829, 830-857, 866-894
4
0.76
6FCU
A
Q9HZI6
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / J
126-159, 175-203, 226-266, 292-322, 323-354, 355-390, 421-453, 593-631
8
0.73