Database of Structural Repeats in Proteins



HEAT repeat - HEAT


The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes. The HEAT repeats consist of pairs of antiparallel alpha helices.

Link to other db

InterPro:

IPR000357

Pfam:

PF02985

Number of PDB chains with HEAT repeat: 1114
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5Y3R
C
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
10-49, 50-95, 100-146, 276-308, 444-474, 638-669, 848-876, 923-974, 1438-1471, 1578-1609, 1970-2001, 2023-2064, 2376-2414, 2487-2515, 2787-2815, 2849-2879, 2909-2944, 2978-3018, 3161-3199, 3252-3294, 3430-3458, 3495-3531, 3602-3630, 3973-4011, 4082-4117
25
0.75
5LUQ
A
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
10-48, 49-77, 289-329, 431-473, 632-670, 1002-1041, 1057-1091, 1109-1137, 1971-2006, 2022-2065, 2115-2149, 2150-2178, 2201-2231, 2295-2334, 2335-2377, 2372-2412, 2614-2647, 2826-2865, 2902-2941, 2983-3021, 3025-3058, 3115-3150
22
0.78
5LUQ
B
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
10-49, 50-77, 259-286, 289-329, 431-473, 701-747, 758-787, 905-946, 1001-1041, 1056-1094, 1095-1142, 1958-1996, 2293-2333, 2335-2378, 2413-2440, 2494-2534, 2903-2941, 3115-3150, 3549-3594, 4083-4120
20
0.78
6EZ8
A
P42858
Huntingtin, myristoylated N-terminal fragment
Homo sapiens (Human)
116-158, 241-281, 348-390, 741-779, 798-836, 898-936, 996-1034, 1255-1283, 1284-1318, 1468-1499, 1655-1682, 1943-1975, 1993-2026, 2029-2062, 2753-2792, 2945-2983, 2984-3019, 3045-3076
18
0.67
6Q84
A
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
36-69, 216-244, 286-313, 345-385, 414-447, 483-512, 524-562, 563-594, 595-622, 642-677, 800-842, 848-886, 889-935, 938-976, 977-1009, 1045-1073
16
0.79
4FGV
A
G0RZB7
CRM1_C domain-containing protein {ECO:0000259|SMART:SM01102}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
97-125, 126-162, 169-217, 224-260, 285-325, 345-377, 466-506, 528-555, 571-603, 607-643, 672-700, 733-765, 793-833, 837-864, 907-955
15
0.81
6G90
O
P49955
U2 snRNP component HSH155
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
215-255, 274-310, 311-364, 386-427, 428-470, 513-551, 552-593, 594-634, 635-674, 678-720, 721-758, 759-793, 794-828, 829-871, 872-911
15
0.87
5W1R
A
P78527
DNA-dependent protein kinase catalytic subunit
Homo sapiens (Human)
65-100, 290-329, 713-741, 749-784, 999-1041, 1056-1094, 1095-1123, 1377-1419, 1560-1589, 1973-2011, 2251-2282, 2448-2486, 2777-2805, 2821-2854, 3085-3113
15
0.76
4A0C
B
Q86VP6
Cullin-associated NEDD8-dissociated protein 1
Homo sapiens (Human)
3-41, 43-78, 81-114, 125-171, 253-286, 376-407, 424-469, 513-554, 606-643, 689-727, 823-855, 856-887, 888-926, 928-971, 1000-1041
15
0.81
5T15
E
P11716
Ryanodine receptor 1
Oryctolagus cuniculus (Rabbit)
454-494, 501-540, 595-624, 1644-1673, 2111-2138, 2439-2471, 2567-2600, 2610-2640, 2644-2674, 3316-3348, 3393-3431, 3435-3468, 3944-3982, 4155-4185
14
0.66
2NYM
D
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
9-43, 44-73, 119-157, 160-197, 198-234, 235-275, 276-316, 318-351, 357-395, 397-434, 436-474, 480-520, 514-552, 553-589
14
0.81
3NC1
A
Q6P5F9
Exportin-1
Mus musculus (Mouse)
116-148, 161-201, 244-272, 300-339, 358-385, 531-558, 574-606, 610-643, 674-703, 704-739, 740-765, 868-907, 908-955, 987-1025
14
0.78
2NPP
A
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
8-43, 83-120, 121-159, 160-197, 198-236, 237-275, 276-313, 317-357, 358-395, 397-435, 436-474, 483-513, 514-552, 553-589
14
0.86
4XRI
A
G0S143
Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
37-73, 90-130, 131-166, 189-216, 219-265, 266-306, 366-398, 404-449, 450-492, 493-518, 564-612, 656-696, 704-739, 832-869
14
0.79
5T15
I
P11716
Ryanodine receptor 1
Oryctolagus cuniculus (Rabbit)
454-494, 501-540, 595-624, 1644-1673, 2111-2138, 2439-2471, 2567-2600, 2610-2640, 2644-2674, 3316-3348, 3393-3431, 3435-3468, 3944-3982, 4155-4185
14
0.66
3WYG
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
84-131, 132-168, 176-225, 307-355, 479-520, 521-568, 563-611, 615-657, 693-746, 780-825, 827-876, 877-917, 922-968, 1003-1039
14
0.85
5VE8
B
Q6CMF0
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
40-76, 77-119, 120-154, 155-199, 253-296, 351-385, 389-450, 533-566, 685-727, 760-788, 860-899, 900-938, 993-1031, 1081-1113
14
0.80
5T15
B
P11716
Ryanodine receptor 1
Oryctolagus cuniculus (Rabbit)
454-494, 501-540, 595-624, 1644-1673, 2111-2138, 2439-2471, 2567-2600, 2609-2640, 2644-2674, 3316-3348, 3393-3431, 3435-3468, 3944-3982, 4155-4185
14
0.66
5T15
G
P11716
Ryanodine receptor 1
Oryctolagus cuniculus (Rabbit)
454-494, 501-540, 595-624, 1644-1673, 2111-2138, 2439-2471, 2567-2600, 2610-2640, 2644-2674, 3316-3348, 3393-3431, 3435-3468, 3944-3982, 4155-4185
14
0.66
2NYL
A
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
8-43, 44-74, 119-157, 160-197, 198-236, 237-274, 275-312, 318-351, 357-395, 397-425, 436-480, 482-511, 514-557, 558-589
14
0.79
2XWU
B
O94829
Importin-13
Homo sapiens (Human)
22-54, 55-89, 94-136, 184-234, 235-274, 276-325, 327-373, 523-562, 563-602, 676-720, 721-757, 760-804, 805-848, 852-909
14
0.86
5ZPU
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
45-83, 84-132, 133-171, 176-225, 334-376, 479-520, 521-569, 570-614, 615-657, 780-826, 827-870, 871-918, 922-968, 1003-1040
14
0.88
3ND2
A
Q06142
Importin subunit beta-1 {ECO:0000303|PubMed:9321403}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
19-54, 90-130, 132-170, 171-217, 219-275, 402-446, 448-486, 492-533, 555-593, 610-649, 696-733, 741-773, 775-812, 825-861
14
0.77
2QMR
B
Q92973
Transportin-1
Homo sapiens (Human)
86-125, 126-158, 171-211, 223-250, 251-294, 394-433, 435-473, 477-510, 637-665, 666-702, 703-740, 760-791, 793-828, 829-864
14
0.79
4HZK
A
G0RZB7
CRM1_C domain-containing protein {ECO:0000259|SMART:SM01102}
Chaetomium thermophilum (strain DSM 1495 / CBS 144
125-164, 169-217, 224-253, 295-327, 397-426, 466-506, 528-555, 572-603, 672-702, 733-765, 837-864, 865-906, 907-956
13
0.79
4C0Q
A
Q9Y5L0
Transportin-3 {ECO:0000303|PubMed:23667635}
Homo sapiens (Human)
40-78, 79-121, 122-154, 216-258, 266-312, 414-453, 454-494, 495-530, 531-573, 634-671, 717-763, 764-806, 814-864
13
0.84
4HAU
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
44-83, 84-132, 176-225, 307-355, 479-520, 521-569, 563-611, 615-657, 780-826, 827-876, 877-918, 922-968, 1003-1040
13
0.86
5DI9
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
47-83, 104-135, 136-168, 296-333, 480-520, 542-569, 570-611, 621-657, 685-746, 747-775, 879-918, 949-972, 1005-1043
13
0.81
6Q82
A
P32767
Importin beta-like protein KAP122
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
34-67, 80-129, 225-261, 273-312, 397-444, 575-622, 643-680, 674-718, 796-835, 839-883, 889-928, 937-973, 977-1023
13
0.77
3WYF
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
44-81, 84-131, 132-168, 176-225, 307-355, 479-520, 521-568, 563-611, 615-657, 686-745, 827-876, 877-918, 922-968
13
0.87
3WYF
F
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
44-81, 84-131, 132-170, 176-225, 334-376, 479-520, 521-568, 563-611, 615-657, 780-826, 827-876, 922-968, 1003-1040
13
0.88
6EPC
Z
Q4FZT9
26S proteasome non-ATPase regulatory subunit 2
Rattus norvegicus (Rat)
42-90, 92-135, 172-218, 242-272, 357-387, 388-424, 425-461, 462-494, 503-534, 535-566, 644-682, 685-715, 721-753
13
0.73
5UWP
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
47-83, 104-135, 136-168, 296-333, 480-520, 515-541, 542-569, 570-611, 621-657, 686-746, 747-776, 879-918, 922-969
13
0.81
5J3V
B
Q92973
Transportin-1
Homo sapiens (Human)
55-82, 87-125, 129-167, 171-211, 224-251, 253-291, 394-433, 435-473, 477-511, 638-665, 666-704, 705-739, 760-791
13
0.76
3M1I
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
44-83, 84-131, 132-170, 176-225, 334-376, 479-520, 523-569, 563-610, 615-657, 780-826, 827-876, 877-917, 1003-1040
13
0.88
2IAE
A
Q76MZ3
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Mus musculus (Mouse)
9-44, 45-76, 120-148, 160-197, 198-238, 239-275, 316-357, 358-396, 397-437, 438-477, 478-513, 514-555, 556-589
13
0.82
3FGA
A
Q76MZ3
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Mus musculus (Mouse)
7-41, 43-74, 121-159, 160-197, 237-275, 276-313, 317-357, 358-395, 396-434, 436-474, 481-513, 514-552, 553-589
13
0.83
5W0V
A
Q6CMF0
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1
39-72, 80-119, 120-154, 155-199, 203-250, 252-296, 351-388, 389-428, 430-470, 532-563, 685-726, 760-787, 858-899
13
0.78
4HAV
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
45-82, 84-132, 133-168, 176-225, 334-376, 479-520, 521-569, 563-611, 615-657, 780-826, 827-870, 871-918, 1003-1040
13
0.84
2NPP
D
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
8-43, 83-120, 121-157, 160-197, 198-234, 237-275, 317-357, 358-395, 397-435, 436-474, 480-513, 514-552, 553-589
13
0.88
3W3T
A
P32337
Importin subunit beta-3 {ECO:0000305}
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
43-79, 96-130, 136-174, 175-212, 274-303, 364-403, 405-439, 443-488, 490-545, 669-714, 741-786, 853-889, 900-934
13
0.84
4OE1
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
134-163, 172-201, 278-309, 349-378, 379-414, 415-449, 455-482, 489-518, 541-576, 592-624, 625-657, 664-696, 697-726
13
0.65
5DIS
A
O14980
Exportin-1
Homo sapiens (Human)
59-95, 117-147, 148-180, 244-273, 303-340, 469-504, 531-558, 574-606, 610-646, 675-703, 736-765, 868-907, 908-956
13
0.77
1QGR
A
Q14974
Importin subunit beta-1
Homo sapiens (Human)
33-69, 70-107, 139-166, 167-210, 212-251, 256-303, 399-443, 447-481, 500-542, 564-596, 661-701, 745-782, 840-876
13
0.79
4CR3
N
P32565
26S proteasome regulatory subunit RPN2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
18-53, 54-92, 131-160, 359-386, 416-454, 459-489, 495-528, 529-564, 565-595, 597-629, 633-664, 674-708, 727-757
13
0.61
4HAT
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
45-83, 84-132, 133-168, 176-225, 334-376, 479-520, 521-569, 563-611, 615-657, 780-826, 827-876, 877-918, 1003-1040
13
0.85
5XOJ
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
27-60, 104-135, 176-221, 232-262, 480-513, 515-541, 542-569, 570-611, 621-657, 686-746, 747-775, 879-918, 922-969
13
0.78
2NYL
D
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
8-43, 44-73, 119-157, 160-197, 198-234, 235-274, 275-312, 318-351, 357-395, 397-426, 436-479, 482-527, 553-589
13
0.81
2Z5O
A
Q92973
Transportin-1
Homo sapiens (Human)
57-84, 85-125, 128-167, 171-211, 213-245, 251-288, 435-473, 477-511, 582-630, 637-665, 666-702, 703-759, 760-788
13
0.77
5UWI
C
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
47-83, 104-135, 136-168, 296-333, 480-514, 515-541, 542-569, 570-611, 621-657, 686-746, 879-918, 922-969, 1005-1043
13
0.79