Database of Structural Repeats in Proteins



HEAT repeat - HEAT


The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes. The HEAT repeats consist of pairs of antiparallel alpha helices.

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InterPro:

IPR000357

Pfam:

PF02985

Number of PDB chains with HEAT repeat: 1114
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
3GS3
A
Q8MSU4
Symplekin {ECO:0000312|EMBL:AAF51962.2}
Drosophila melanogaster (Fruit fly)
22-59, 60-112, 140-170
3
0.94
5H64
A
P42345
Serine/threonine-protein kinase mTOR
Homo sapiens (Human)
591-628, 631-665, 677-710, 749-785, 793-835, 836-874, 988-1029, 1316-1351, 1612-1650, 1651-1692
10
0.93
5H64
a
P42345
Serine/threonine-protein kinase mTOR
Homo sapiens (Human)
591-628, 631-665, 677-710, 754-793, 794-835, 836-874, 988-1029, 1316-1351, 1612-1650, 1651-1692
10
0.92
2Y3U
A
Q9X721
Collagenase ColG {ECO:0000303|PubMed:9922257}
Hathewaya histolytica (Clostridium histolyticum)
160-202, 212-255, 256-301
3
0.91
1JK0
B
P49723
Ribonucleoside-diphosphate reductase small chain 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
100-142, 153-189, 190-235
3
0.91
3VYC
A
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
130-167, 177-225, 336-376, 479-520, 521-568, 563-611, 615-657, 686-745, 827-876, 1003-1040
10
0.91
2KM4
A
Q05543
Regulator of Ty1 transposition protein 103
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
5-51, 54-99, 100-138
3
0.91
6CWQ
A
A5FCJ5
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cyto
68-111, 124-163, 164-212
3
0.91
2R17
D
Q96QK1
Vacuolar protein sorting-associated protein 35
Homo sapiens (Human)
503-548, 552-596, 597-641, 642-678
4
0.91
3NMZ
B
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
377-427, 471-512, 513-556, 557-599, 600-647, 648-690, 691-732
7
0.91
5CLC
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.90
5IZ6
A
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-599, 609-647, 648-690, 691-732
6
0.90
2NPP
B
Q13362
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Homo sapiens (Human)
142-184, 185-227, 228-269, 270-303
4
0.90
5DLQ
A
Q9ESJ0
Exportin-4
Mus musculus (Mouse)
47-84, 85-129, 130-168, 184-238, 263-307, 673-713, 826-869
7
0.90
6NPW
A
Q8MSU4
Symplekin {ECO:0000312|EMBL:AAF51962.2}
Drosophila melanogaster (Fruit fly)
21-58, 59-112, 140-170, 198-235
4
0.90
3NMX
C
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-599, 609-649, 650-690, 691-732
6
0.90
4K92
B
Q7Z460
CLIP-associating protein 1
Homo sapiens (Human)
317-360, 412-443, 444-479, 482-517
4
0.90
4UQI
A
P18484
AP-2 complex subunit alpha-2
Rattus norvegicus (Rat)
71-105, 106-140, 141-183, 184-222, 519-552, 553-591
6
0.90
6RK9
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.90
6BZX
A
-
-
-
11-45, 46-85, 104-147, 166-209, 229-260
5
0.90
2DB0
B
O58277
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR
30-63, 64-113, 114-154, 181-212
4
0.89
1X81
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
94-144, 200-248, 249-288, 289-327
4
0.89
3SPY
A
Q38087
DNA-directed DNA polymerase {ECO:0000255|HAMAP-Rule:MF_04100}
Enterobacteria phage RB69 (Bacteriophage RB69)
468-506, 524-570, 571-609, 729-773
4
0.89
4K92
A
Q7Z460
CLIP-associating protein 1
Homo sapiens (Human)
317-360, 412-443, 444-479, 482-517
4
0.89
5UUF
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5DLQ
B
Q9ESJ0
Exportin-4
Mus musculus (Mouse)
47-84, 85-129, 130-167, 185-238, 263-307, 603-650, 722-763, 826-869, 949-991, 993-1034
10
0.89
5CL8
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5JZ8
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.89
6M9M
A
A0A0M3KL00
Streptococcus mutans
34-67, 68-103, 104-137, 141-185
4
0.89
6FF4
u
O75533
Splicing factor 3B subunit 1
Homo sapiens (Human)
656-697, 698-738, 778-819, 821-861, 862-902, 904-945, 983-1024, 1025-1063, 1067-1108, 1141-1181, 1182-1221, 1223-1258
12
0.89
4FZD
A
Q9Y376
Calcium-binding protein 39
Homo sapiens (Human)
77-111, 123-162, 163-195, 251-288
4
0.89
5CL6
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
6FF7
u
O75533
Splicing factor 3B subunit 1
Homo sapiens (Human)
1069-1100, 1104-1138, 1141-1178, 1180-1218, 1223-1257
5
0.89
2DB0
A
O58277
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBR
29-63, 64-115, 116-153, 181-212
4
0.89
5JZZ
A
-
-
-
355-393, 410-451, 452-485
3
0.89
5CL5
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5CL3
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5CL7
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
4YJE
A
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-598, 609-649, 650-690, 691-733
6
0.89
5UUH
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5CLA
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
1W9C
A
O14980
Exportin-1
Homo sapiens (Human)
736-767, 866-907, 908-956, 970-1024
4
0.89
3O2Q
A
Q92797
Symplekin
Homo sapiens (Human)
28-66, 67-103, 104-146, 152-194, 268-315
5
0.89
6O07
A
G2WCC0
Saccharomyces cerevisiae (strain Kyokai no
309-354, 359-399, 414-449
3
0.89
6CWO
B
A5FCJ5
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cyto
68-111, 124-163, 164-212
3
0.89
3ZJY
B
O94829
Importin-13
Homo sapiens (Human)
55-90, 93-135, 184-235, 236-274, 276-325, 523-562, 563-602, 676-719, 805-848, 910-951
10
0.89
5JQY
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.89
5CL4
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
4CRV
B
Q92600
CCR4-NOT transcription complex subunit 9 {ECO:0000312|HGNC:HGNC:10445}
Homo sapiens (Human)
15-50, 115-160, 161-192, 203-242
4
0.88
3PZD
A
Q9HD67
Unconventional myosin-X
Homo sapiens (Human)
1562-1599, 1600-1642, 1643-1682, 1801-1843
4
0.88