Database of Structural Repeats in Proteins



Pumilio repeat - Pumilio


Members of the Pumilio family of proteins (Puf) regulate translation and mRNA stability in a wide variety of eukaryotic organisms including mammals, flies, worms, slime mold, and yeast. Pumilio family members are characterised by the presence of tandem copies of an imperfectly repeated 36 amino acids sequence motif, the Pumilio repeat, surrounded by a short N- and C-terminal conserved region. The Puf family of proteins are mainly post-transcriptional regulators. Several Puf members have been shown to bind specific RNA sequences mainly found in the 3' UTR of mRNA and repress their translation. Frequently, Puf proteins function asymmetrically to create protein gradients, thus causing asymmetric cell division and regulating cell fate specification.

Link to other db

InterPro:

IPR001313

PROSITE:

PS50302

SMART:

SM00025

Pfam:

PF00806

Number of PDB chains with Pumilio repeat: 92
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5A1X
E
Q9QZE5
Coatomer subunit gamma-1
Mus musculus (Mouse)
110-142, 143-177, 187-218, 520-548
4
0.81
5A1Y
M
Q9QZE5
Coatomer subunit gamma-1
Mus musculus (Mouse)
110-142, 143-177, 187-218, 520-548
4
0.81
5WZG
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-384, 422-461, 498-526, 529-564, 565-590
8
0.86
5WZI
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-384, 385-421, 431-461, 498-525, 529-565, 566-603
9
0.82
5WZK
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 254-294, 310-349, 359-387, 466-492, 495-531
6
0.80
5WZH
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-383, 384-421, 431-461, 498-526, 529-564, 565-590, 591-621
10
0.81
5WZJ
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
386-422, 431-462, 494-528, 529-567, 568-610
5
0.91
5LN3
N
Q99460
26S proteasome non-ATPase regulatory subunit 1
Homo sapiens (Human)
17-50, 213-241, 390-426, 469-503, 504-538, 539-572, 573-608, 643-677
8
0.75
3Q0S
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
727-752, 753-799, 800-836, 837-873, 874-911, 912-945, 946-983, 986-1027
8
0.94
3Q0R
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
728-765, 766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
7
0.94
3Q0Q
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
6
0.94
3GVT
B
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
728-765, 766-799, 800-828, 837-872, 873-898, 899-945, 946-983, 987-1027
8
0.93
3GVT
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
766-799, 800-828, 837-873, 899-945, 946-983, 987-1027
6
0.93
3GVO
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
727-764, 765-799, 800-828, 838-873, 899-944, 945-983, 987-1025
7
0.92
3GJX
D
Q6P5F9
Exportin-1
Mus musculus (Mouse)
16-51, 213-248, 254-289, 447-479, 494-519, 534-566, 683-718, 743-777
8
0.83
4WZW
A
Q15397
Pumilio homolog 3 {ECO:0000305}
Homo sapiens (Human)
131-166, 167-201, 202-238, 319-352, 353-386, 387-413, 414-455, 507-532, 587-625
9
0.81
3Q0P
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.94
1M8W
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0P
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-992, 993-1031, 1032-1065, 1066-1103, 1107-1145
8
0.95
3Q0O
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0O
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103
5
0.95
3Q0L
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1147
6
0.94
3Q0L
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-955, 956-992, 993-1030, 1031-1065, 1066-1103, 1106-1145
8
0.95
3Q0M
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 994-1031, 1032-1065, 1066-1101, 1106-1143
8
0.94
3Q0M
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-957, 958-991, 992-1032, 1033-1065, 1066-1103, 1106-1133, 1134-1167
8
0.88
3Q0N
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
885-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0N
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-955, 956-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
1IB2
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
7
0.93
1M8W
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
7
0.95
1M8X
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.94
1M8X
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-884, 885-921, 922-957, 958-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
1M8Y
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
7
0.94
1M8Y
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-920, 921-955, 956-993, 994-1031, 1032-1065, 1066-1096, 1106-1141, 1142-1169
8
0.91
3BSX
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-957, 958-993, 1019-1065, 1066-1102, 1105-1145
6
0.94
3BSX
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.95
3BSB
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
6
0.94
3BSB
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
848-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1101, 1107-1145
7
0.94
2YJY
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1133
6
0.95
2YJY
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1103
6
0.95
1M8Z
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1142
7
0.94
4HMY
B
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
96-130, 294-328, 332-362, 363-400, 401-434, 442-469, 478-510, 511-542
8
0.76
4P6Z
B
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
96-131, 132-160, 294-321, 365-400, 401-434, 438-468, 469-498, 499-532
8
0.81
6NOD
A
Q09487
Caenorhabditis elegans
195-227, 228-269, 270-305, 306-341, 342-381, 382-417, 418-453, 457-495
8
0.95
6NOD
B
Q09487
Caenorhabditis elegans
195-227, 228-268, 269-305, 306-341, 342-381, 405-453, 456-495
7
0.95
6NOD
C
Q09487
Caenorhabditis elegans
195-227, 228-268, 269-305, 306-341, 342-368, 405-453, 457-495
7
0.95
3K62
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-259, 276-308, 321-348, 349-383, 411-439, 440-478, 485-520
7
0.87
3V74
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-260, 276-308, 321-348, 349-382, 411-439, 440-477
6
0.88
3K5Y
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 276-308, 321-348, 349-383, 404-439, 440-478, 485-520
7
0.88
3V6Y
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 283-308, 321-348, 349-383, 404-439, 440-477
6
0.88
3QGB
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 283-308, 309-348, 349-382, 411-439, 440-478, 485-520
7
0.92