Database of Structural Repeats in Proteins



Pumilio repeat - Pumilio


Members of the Pumilio family of proteins (Puf) regulate translation and mRNA stability in a wide variety of eukaryotic organisms including mammals, flies, worms, slime mold, and yeast. Pumilio family members are characterised by the presence of tandem copies of an imperfectly repeated 36 amino acids sequence motif, the Pumilio repeat, surrounded by a short N- and C-terminal conserved region. The Puf family of proteins are mainly post-transcriptional regulators. Several Puf members have been shown to bind specific RNA sequences mainly found in the 3' UTR of mRNA and repress their translation. Frequently, Puf proteins function asymmetrically to create protein gradients, thus causing asymmetric cell division and regulating cell fate specification.

Link to other db

InterPro:

IPR001313

PROSITE:

PS50302

SMART:

SM00025

Pfam:

PF00806

Number of PDB chains with Pumilio repeat: 92
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
1M8W
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0L
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-955, 956-992, 993-1030, 1031-1065, 1066-1103, 1106-1145
8
0.95
6NOD
B
Q09487
Caenorhabditis elegans
195-227, 228-268, 269-305, 306-341, 342-381, 405-453, 456-495
7
0.95
3QG9
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
177-216, 217-259, 260-298, 299-336, 337-378
5
0.95
6NOD
A
Q09487
Caenorhabditis elegans
195-227, 228-269, 270-305, 306-341, 342-381, 382-417, 418-453, 457-495
8
0.95
3Q0N
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
885-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0N
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-955, 956-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
3Q0O
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3Q0O
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103
5
0.95
3Q0P
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-992, 993-1031, 1032-1065, 1066-1103, 1107-1145
8
0.95
3BSX
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.95
2YJY
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1133
6
0.95
2YJY
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1103
6
0.95
1M8W
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
7
0.95
5KLA
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1138-1184, 1185-1219, 1220-1256, 1282-1327, 1328-1366, 1367-1405
6
0.95
1M8X
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-884, 885-921, 922-957, 958-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
6NOD
C
Q09487
Caenorhabditis elegans
195-227, 228-268, 269-305, 306-341, 342-368, 405-453, 457-495
7
0.95
3BSB
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
848-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1101, 1107-1145
7
0.94
3Q0L
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1147
6
0.94
1M8X
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.94
5BYM
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-438, 439-472
6
0.94
3Q0M
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 994-1031, 1032-1065, 1066-1101, 1106-1143
8
0.94
5KL1
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1150-1184, 1185-1220, 1221-1255, 1256-1281, 1282-1327, 1328-1364, 1367-1402
7
0.94
3K4E
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-717, 718-747, 748-795, 808-835
8
0.94
3K4E
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
3K4E
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
1M8Y
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
7
0.94
1M8Z
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1142
7
0.94
3Q0S
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
727-752, 753-799, 800-836, 837-873, 874-911, 912-945, 946-983, 986-1027
8
0.94
3Q0P
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.94
3Q0Q
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
6
0.94
5KL8
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1148-1183, 1184-1219, 1220-1254, 1255-1281, 1282-1327, 1328-1365, 1367-1402
7
0.94
3BX3
B
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
602-637, 638-664, 665-698, 699-746, 747-775, 776-822, 823-852
7
0.94
3Q0R
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
728-765, 766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
7
0.94
3BX2
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
590-637, 638-674, 675-701, 702-747, 748-776
5
0.94
3BSX
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-957, 958-993, 1019-1065, 1066-1102, 1105-1145
6
0.94
3BSB
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
6
0.94
3K49
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-679, 683-718, 719-747, 764-795, 809-835
8
0.93
5BZU
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-439, 440-472
6
0.93
3K49
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
3K49
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
1IB2
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
7
0.93
3H3D
Y
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
361-396, 397-442, 443-479, 480-507, 508-551, 552-587, 590-625
7
0.93
3H3D
X
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
47-82, 83-129, 130-165, 166-204, 205-237, 238-274, 276-311
7
0.93
3GVT
B
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
728-765, 766-799, 800-828, 837-872, 873-898, 899-945, 946-983, 987-1027
8
0.93
3GVT
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
766-799, 800-828, 837-873, 899-945, 946-983, 987-1027
6
0.93
3BX3
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
564-601, 602-637, 638-664, 665-698, 699-746, 747-775, 787-822, 823-852
8
0.93
5BZ5
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-439, 440-472
6
0.93
3QGB
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 283-308, 309-348, 349-382, 411-439, 440-478, 485-520
7
0.92
3QGC
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-260, 283-308, 310-348, 349-383, 411-439, 440-478, 485-520
7
0.92