Database of Structural Repeats in Proteins



Pumilio repeat - Pumilio


Members of the Pumilio family of proteins (Puf) regulate translation and mRNA stability in a wide variety of eukaryotic organisms including mammals, flies, worms, slime mold, and yeast. Pumilio family members are characterised by the presence of tandem copies of an imperfectly repeated 36 amino acids sequence motif, the Pumilio repeat, surrounded by a short N- and C-terminal conserved region. The Puf family of proteins are mainly post-transcriptional regulators. Several Puf members have been shown to bind specific RNA sequences mainly found in the 3' UTR of mRNA and repress their translation. Frequently, Puf proteins function asymmetrically to create protein gradients, thus causing asymmetric cell division and regulating cell fate specification.

Link to other db

InterPro:

IPR001313

PROSITE:

PS50302

SMART:

SM00025

Pfam:

PF00806

Number of PDB chains with Pumilio repeat: 92
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5WZH
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-383, 384-421, 431-461, 498-526, 529-564, 565-590, 591-621
10
0.81
4CJ9
A
E5AV36
Burkholderia TALE-like protein 1 {ECO:0000303|PubMed:24792163}
Paraburkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
19-48, 51-82, 282-314, 348-380, 381-413, 414-443, 513-545, 546-578, 678-709, 740-766
10
0.76
3UGM
A
B2SU53
TAL effector protein PthXo1 {ECO:0000303|PubMed:22223736}
Xanthomonas oryzae pv
324-357, 358-391, 460-493, 562-591, 731-764, 765-790, 833-866, 867-897, 902-930, 970-998
10
0.81
4CJ9
B
E5AV36
Burkholderia TALE-like protein 1 {ECO:0000303|PubMed:24792163}
Paraburkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
19-48, 51-82, 216-248, 249-280, 282-314, 348-380, 480-512, 513-545, 579-611, 740-766
10
0.68
4WZW
A
Q15397
Pumilio homolog 3 {ECO:0000305}
Homo sapiens (Human)
131-166, 167-201, 202-238, 319-352, 353-386, 387-413, 414-455, 507-532, 587-625
9
0.81
5WTY
A
P47077
Nucleolar protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
94-128, 129-163, 333-372, 373-410, 411-450, 482-511, 514-540, 541-578, 592-617
9
0.83
5WZI
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-384, 385-421, 431-461, 498-525, 529-565, 566-603
9
0.82
3Q0L
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-955, 956-992, 993-1030, 1031-1065, 1066-1103, 1106-1145
8
0.95
3K49
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-679, 683-718, 719-747, 764-795, 809-835
8
0.93
6NOD
A
Q09487
Caenorhabditis elegans
195-227, 228-269, 270-305, 306-341, 342-381, 382-417, 418-453, 457-495
8
0.95
3K49
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
3K49
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
3K4E
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
3K4E
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
3K4E
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-717, 718-747, 748-795, 808-835
8
0.94
4P6Z
B
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
96-131, 132-160, 294-321, 365-400, 401-434, 438-468, 469-498, 499-532
8
0.81
3Q0M
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 994-1031, 1032-1065, 1066-1101, 1106-1143
8
0.94
3Q0M
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-957, 958-991, 992-1032, 1033-1065, 1066-1103, 1106-1133, 1134-1167
8
0.88
3Q0N
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-955, 956-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
3Q0S
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
727-752, 753-799, 800-836, 837-873, 874-911, 912-945, 946-983, 986-1027
8
0.94
3Q0P
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-992, 993-1031, 1032-1065, 1066-1103, 1107-1145
8
0.95
4HMY
B
Q10567
AP-1 complex subunit beta-1
Homo sapiens (Human)
96-130, 294-328, 332-362, 363-400, 401-434, 442-469, 478-510, 511-542
8
0.76
3GVT
B
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
728-765, 766-799, 800-828, 837-872, 873-898, 899-945, 946-983, 987-1027
8
0.93
5WZG
A
Q9C552
Pumilio homolog 23
Arabidopsis thaliana (Mouse-ear cress)
124-149, 211-242, 288-328, 344-384, 422-461, 498-526, 529-564, 565-590
8
0.86
3GJX
D
Q6P5F9
Exportin-1
Mus musculus (Mouse)
16-51, 213-248, 254-289, 447-479, 494-519, 534-566, 683-718, 743-777
8
0.83
3BX3
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
564-601, 602-637, 638-664, 665-698, 699-746, 747-775, 787-822, 823-852
8
0.93
1M8X
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-884, 885-921, 922-957, 958-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
4UQI
B
P63010
AP-2 complex subunit beta
Homo sapiens (Human)
27-57, 97-130, 294-324, 365-401, 402-434, 442-469, 472-513, 514-542
8
0.78
5LN3
N
Q99460
26S proteasome non-ATPase regulatory subunit 1
Homo sapiens (Human)
17-50, 213-241, 390-426, 469-503, 504-538, 539-572, 573-608, 643-677
8
0.75
4CJA
A
E5AV36
Burkholderia TALE-like protein 1 {ECO:0000303|PubMed:24792163}
Paraburkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)
51-82, 249-281, 282-314, 315-347, 348-380, 381-413, 645-677, 711-739
8
0.82
1M8Y
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-920, 921-955, 956-993, 994-1031, 1032-1065, 1066-1096, 1106-1141, 1142-1169
8
0.91
5BZ1
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
222-250, 251-286, 287-322, 326-365, 366-391, 392-441, 442-474
7
0.87
3QGC
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-260, 283-308, 310-348, 349-383, 411-439, 440-478, 485-520
7
0.92
2JKR
B
P63010
AP-2 complex subunit beta
Homo sapiens (Human)
87-130, 131-160, 291-324, 364-401, 404-433, 434-460, 472-513
7
0.83
5KL8
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1148-1183, 1184-1219, 1220-1254, 1255-1281, 1282-1327, 1328-1365, 1367-1402
7
0.94
1M8Z
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1142
7
0.94
1M8Y
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
7
0.94
3Q0R
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
728-765, 766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
7
0.94
1M8W
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
7
0.95
3QGB
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 283-308, 309-348, 349-382, 411-439, 440-478, 485-520
7
0.92
2VGL
B
P63010
AP-2 complex subunit beta
Homo sapiens (Human)
27-57, 61-87, 200-233, 294-325, 332-362, 364-401, 428-471
7
0.72
3BSB
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
848-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1101, 1107-1145
7
0.94
3K62
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-259, 276-308, 321-348, 349-383, 411-439, 440-478, 485-520
7
0.87
3K61
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 276-308, 310-348, 349-382, 411-439, 440-478, 485-520
7
0.92
3K5Z
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-260, 283-308, 321-348, 349-382, 411-439, 440-478, 485-520
7
0.87
3V71
A
O44169
Pumilio domain-containing protein 7 {ECO:0000303|PubMed:17234175}
Caenorhabditis elegans
129-168, 169-204, 214-240, 244-270, 298-327, 328-363, 373-403
7
0.83
3BX3
B
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
602-637, 638-664, 665-698, 699-746, 747-775, 776-822, 823-852
7
0.94
3GVO
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
727-764, 765-799, 800-828, 838-873, 899-944, 945-983, 987-1025
7
0.92
3H3D
Y
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
361-396, 397-442, 443-479, 480-507, 508-551, 552-587, 590-625
7
0.93
3H3D
X
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
47-82, 83-129, 130-165, 166-204, 205-237, 238-274, 276-311
7
0.93