Database of Structural Repeats in Proteins



Leucine-rich repeat - LRR


Leucine-rich repeats consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions.Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response.

Link to other db

InterPro:

IPR001611

PROSITE:

PS51450

Pfam:

PF00560

Number of PDB chains with LRR repeat: 6857
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
4Z61
C
Q9XIC7
Somatic embryogenesis receptor kinase 2
Arabidopsis thaliana (Mouse-ear cress)
99-120, 123-144, 147-168, 171-192
4
0.94
3RW6
B
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.94
4XM4
C
G0SET4
Chaetomium thermophilum (strain DSM 1495 / CBS 144
263-285, 288-309, 313-338
3
0.94
3DZE
A
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
62-82, 85-107, 115-136, 139-164
4
0.94
4M7E
D
Q94F62
BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 {ECO:0000303|PubMed:12150929}
Arabidopsis thaliana (Mouse-ear cress)
95-116, 119-140, 143-164, 167-188
4
0.94
3ZYN
B
P0C192
Leucine-rich repeat-containing protein 4B
Mus musculus (Mouse)
67-87, 89-110, 113-134, 137-158, 161-182, 185-206, 210-231, 232-253, 257-278, 280-301, 305-331
11
0.94
3E2J
B
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
61-82, 85-107, 115-136, 139-163
4
0.94
3E4G
A
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
62-82, 85-107, 115-136, 139-164
4
0.94
1K5D
C
P41391
Ran GTPase-activating protein 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
189-216, 217-244, 245-271
3
0.94
1KOH
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 315-333
3
0.94
1FT8
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.94
5IL7
B
Q8KC98
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / T
38-61, 64-85, 86-107, 108-129, 130-151, 152-173, 174-195, 196-217, 218-239, 240-261, 262-283, 284-305, 306-327, 328-349, 350-371, 373-394
16
0.94
1K5D
L
P41391
Ran GTPase-activating protein 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
189-216, 217-244, 245-271
3
0.94
4Q3G
B
Q01JP8
Oryza sativa (Rice)
101-122, 125-146, 149-170, 173-194
4
0.94
4U08
B
Q72TC3
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhage
49-70, 73-94, 96-118, 119-140, 142-163, 165-186, 188-209, 211-232, 234-255, 257-278, 280-301, 303-324, 326-347, 349-370, 372-393, 395-417
16
0.94
1K5D
I
P41391
Ran GTPase-activating protein 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
189-216, 217-244, 245-271
3
0.94
6G3W
C
Q9XIC7
Somatic embryogenesis receptor kinase 2
Arabidopsis thaliana (Mouse-ear cress)
99-120, 123-144, 147-168, 171-192
4
0.94
3RW7
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-288, 292-313, 316-333
3
0.94
2OMT
A
A4GWM6
Listeria monocytogenes
79-100, 101-122, 123-144, 145-165, 166-186, 187-208, 209-230, 231-252, 253-274, 275-296, 297-318, 319-340, 341-362, 363-384, 385-406
15
0.93
3RW7
C
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
222-243, 266-289, 292-313, 316-333
4
0.93
4BV4
R
Q4G1L2
Eptatretus burgeri (Inshore hagfish)
99-122, 126-146, 150-171, 175-196, 198-219, 222-243, 246-267, 270-291, 294-315, 319-340, 342-363, 367-388, 391-412, 415-432
14
0.93
1FS2
C
Q13309
S-phase kinase-associated protein 2
Homo sapiens (Human)
218-239, 242-266, 269-292, 296-320, 323-344, 348-370, 373-394
7
0.93
4U09
A
Q72NS0
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhage
43-63, 65-86, 88-109, 111-132, 134-155, 157-178, 180-202, 203-224, 227-249, 251-272, 273-293, 295-316, 318-339, 341-362, 364-385, 387-409
16
0.93
1FS2
A
Q13309
S-phase kinase-associated protein 2
Homo sapiens (Human)
218-239, 242-266, 269-292, 296-320, 323-344, 348-370, 372-394
7
0.93
1FT8
C
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
1H6U
A
Q9ZEY1
Listeria monocytogenes
78-98, 99-120, 121-142, 143-164, 165-186, 187-208, 209-230, 231-252
8
0.93
1XEU
A
Q8Y6A8
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
78-99, 100-121, 122-141, 142-162, 163-184, 185-206
6
0.93
3RW7
A
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
119-142, 156-174, 222-243, 266-289, 292-313, 315-333
6
0.93
2JQD
A
O35381
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Mus musculus (Mouse)
19-40, 44-65, 67-88, 90-111, 114-138
5
0.93
4WYK
C
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 315-333
3
0.93
1KOO
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-287, 292-313, 315-334
3
0.93
3E3Z
A
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
62-82, 85-107, 115-136, 139-164
4
0.93
3OJA
B
-
-
-
227-248, 251-272, 275-296, 299-320, 360-381, 382-403, 429-451, 452-473, 474-494
9
0.93
3RW7
B
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
4LSC
A
Q94AG2
Somatic embryogenesis receptor kinase 1
Arabidopsis thaliana (Mouse-ear cress)
70-93, 96-117, 120-141, 144-165, 168-189
5
0.93
3ZYJ
A
Q9HCJ2
Leucine-rich repeat-containing protein 4C
Homo sapiens (Human)
56-77, 78-98, 101-122, 126-147, 149-170, 173-194, 198-219, 220-241, 244-265, 268-289, 292-308
11
0.93
2ID5
A
Q96FE5
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Homo sapiens (Human)
12-33, 34-54, 57-78, 81-102, 105-126, 128-149, 152-173, 177-198, 201-222, 227-248, 249-270, 273-294, 297-318, 322-343
14
0.93
1A9N
A
P09661
U2 small nuclear ribonucleoprotein A'
Homo sapiens (Human)
19-40, 65-86, 89-110, 114-138
4
0.93
1A9N
C
P09661
U2 small nuclear ribonucleoprotein A'
Homo sapiens (Human)
21-43, 65-86, 89-111, 114-138
4
0.93
4FHO
A
-
-
-
79-100, 101-121, 122-142, 143-164, 165-186, 187-208, 209-230, 231-252
8
0.93
1OGQ
A
P58822
Polygalacturonase inhibitor 2
Phaseolus vulgaris (Kidney bean) (French bean)
104-125, 128-149, 152-173, 177-198, 200-221, 224-245, 247-268
7
0.93
4U08
A
Q72TC3
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhage
49-70, 73-94, 96-118, 119-140, 142-163, 165-186, 188-209, 211-232, 235-256, 257-278, 280-301, 303-324, 326-347, 349-370, 372-393, 395-417
16
0.93
4U06
A
Q72U33
Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhage
47-68, 70-91, 93-114, 116-137, 140-161, 162-183, 185-206, 208-229, 231-252, 254-276, 277-298, 300-321, 323-344, 346-368
14
0.93
1FT8
A
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
1D0B
A
P0DQD3
Internalin B {ECO:0000303|PubMed:1905979}
Listeria monocytogenes serotype 1/2a (strain EGD / Mackaness)
79-100, 101-120, 121-142, 143-164, 165-186, 187-208, 209-230
7
0.93
2OMU
A
P0DJM0
Internalin A {ECO:0000303|PubMed:1905979}
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-122, 123-144, 145-164, 165-186, 187-208, 209-230, 231-252, 253-274, 275-296, 297-318, 319-340, 341-362, 363-384, 385-406
15
0.93
4FHO
B
-
-
-
79-100, 101-120, 121-142, 143-164, 165-186, 187-208, 209-230, 231-252
8
0.93
4Q3I
A
Q01JP8
Oryza sativa (Rice)
101-122, 125-146, 149-170, 173-194, 196-212
5
0.93
3O6N
A
-
-
-
227-248, 251-272, 275-296, 299-320, 360-381, 382-403, 429-451, 452-473, 474-494
9
0.93
1OTO
A
P0DQD3
Internalin B {ECO:0000303|PubMed:1905979}
Listeria monocytogenes serotype 1/2a (strain EGD / Mackaness)
79-100, 101-120, 121-142, 143-164, 165-186, 187-208, 209-230
7
0.93