Database of Structural Repeats in Proteins



Ankyrin repeat - ANK


The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90 degree angle. The repeats stack together to form an L-shaped structure

Link to other db

InterPro:

IPR002110

PROSITE:

PS50088

PRINTS:

PRO1415

SMART:

SM00248

Pfam:

PF00023

Number of PDB chains with ANK repeat: 859
1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score
5VKQ
B
E0A9E1
Drosophila melanogaster (Fruit fly)
129-161, 164-192, 197-229, 236-264, 267-299, 300-332, 333-364, 399-431, 432-464, 466-498, 500-532, 533-563, 624-654, 658-690, 691-723, 724-756, 757-789, 791-823, 825-857, 861-893, 894-926, 927-959, 973-1005, 1008-1040, 1042-1074, 1075-1107, 1108-1141
27
0.91
5VKQ
D
E0A9E1
Drosophila melanogaster (Fruit fly)
129-161, 164-192, 197-229, 236-264, 267-299, 300-332, 333-364, 399-431, 432-464, 466-498, 500-532, 533-563, 624-654, 658-690, 691-723, 724-756, 757-789, 791-823, 825-857, 861-893, 894-926, 927-959, 973-1005, 1008-1040, 1042-1074, 1075-1107, 1108-1141
27
0.91
5VKQ
A
E0A9E1
Drosophila melanogaster (Fruit fly)
129-161, 164-192, 197-229, 236-264, 267-299, 300-332, 333-364, 399-431, 432-464, 466-498, 500-532, 533-563, 624-654, 658-690, 691-723, 724-756, 757-789, 791-823, 825-857, 861-893, 894-926, 927-959, 973-1005, 1008-1040, 1042-1074, 1075-1107, 1108-1141
27
0.91
5VKQ
C
E0A9E1
Drosophila melanogaster (Fruit fly)
129-161, 164-192, 197-229, 236-264, 267-299, 300-332, 333-364, 399-431, 432-464, 466-498, 500-532, 533-563, 624-654, 658-690, 691-723, 724-756, 757-789, 791-823, 825-857, 861-893, 894-926, 927-959, 973-1005, 1008-1040, 1042-1074, 1075-1107, 1108-1141
27
0.91
4RLV
A
Q01484
Ankyrin-2
Homo sapiens (Human)
2028-2062, 2063-2095, 2096-2128, 2129-2161, 2162-2188, 2189-2223, 2232-2264, 2265-2298, 2299-2330, 2331-2363, 2364-2395, 2396-2428, 2429-2461, 2462-2494, 2495-2528, 2529-2560, 2561-2593, 2594-2626, 2627-2659, 2660-2693, 2694-2724, 2725-2758, 2759-2790, 2792-2816
24
0.89
5Y4D
A
Q01484
Ankyrin-2
Homo sapiens (Human)
2028-2062, 2063-2095, 2096-2128, 2129-2161, 2162-2186, 2191-2224, 2232-2264, 2265-2297, 2298-2330, 2331-2362, 2363-2395, 2396-2427, 2429-2461, 2462-2494, 2495-2527, 2528-2560, 2561-2593, 2594-2626, 2627-2659
19
0.91
6MOL
A
-
-
-
3-35, 36-68, 69-101, 102-134, 135-166, 168-200, 201-232, 233-265, 266-298, 299-327, 328-360, 361-393, 394-425, 426-454
14
0.92
5LEE
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-182, 203-235, 236-268, 269-301, 302-340, 360-392, 393-425, 427-459, 460-484
13
0.91
5LEB
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-176, 197-229, 230-262, 263-295, 296-328, 349-381, 382-414, 415-447, 448-473
13
0.91
5LEC
A
-
-
-
13-45, 46-78, 79-111, 112-144, 145-182, 203-235, 236-268, 269-300, 302-340, 360-392, 394-426, 427-458, 460-485
13
0.91
1N11
A
P16157
Ankyrin-1
Homo sapiens (Human)
405-435, 436-468, 469-500, 501-533, 534-566, 567-599, 601-633, 634-665, 666-698, 699-731, 732-764, 765-796
12
0.93
5Y4F
A
Q01484
Ankyrin-2
Homo sapiens (Human)
430-462, 463-493, 494-527, 528-560, 561-592, 593-625, 626-657, 659-691, 692-724, 725-757, 758-790, 791-822
12
0.93
4M59
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
173-205, 207-239, 243-275, 279-311, 350-381, 385-419, 525-558, 561-593, 594-624, 631-663, 667-699, 701-733
12
0.85
5LE2
B
-
-
-
13-45, 46-78, 79-111, 112-144, 207-239, 240-271, 272-304, 305-346, 367-399, 400-432, 433-464, 466-491
12
0.91
4OE1
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
173-205, 207-239, 243-275, 279-311, 350-381, 385-419, 525-558, 561-593, 594-624, 631-663, 667-699, 701-733
12
0.85
5Y4F
B
Q01484
Ankyrin-2
Homo sapiens (Human)
430-462, 463-493, 494-527, 528-560, 561-592, 593-625, 626-658, 659-691, 692-724, 725-757, 758-790, 791-819
12
0.93
4M57
A
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
138-172, 173-205, 208-242, 244-276, 280-314, 350-380, 455-489, 525-553, 664-697, 702-735, 737-763
11
0.88
5JHQ
B
O95271
Poly [ADP-ribose] polymerase tankyrase-1 {ECO:0000305}
Homo sapiens (Human)
182-213, 215-247, 248-279, 280-312, 313-345, 367-391, 400-432, 433-465, 520-552, 555-587, 589-621
11
0.89
5JHQ
A
O95271
Poly [ADP-ribose] polymerase tankyrase-1 {ECO:0000305}
Homo sapiens (Human)
181-213, 215-247, 248-279, 280-312, 313-345, 367-391, 400-432, 433-465, 520-552, 555-587, 589-621
11
0.89
5JHQ
D
O95271
Poly [ADP-ribose] polymerase tankyrase-1 {ECO:0000305}
Homo sapiens (Human)
181-213, 215-247, 248-279, 280-312, 313-345, 367-399, 400-432, 433-465, 520-552, 555-587, 589-621
11
0.92
5LE2
A
-
-
-
13-40, 46-78, 79-111, 112-144, 207-239, 240-271, 272-304, 368-400, 401-432, 433-465, 466-491
11
0.89
5LED
A
-
-
-
13-45, 46-78, 79-111, 112-144, 204-236, 237-268, 269-301, 302-340, 361-393, 394-426, 427-458
11
0.93
5JHQ
C
O95271
Poly [ADP-ribose] polymerase tankyrase-1 {ECO:0000305}
Homo sapiens (Human)
182-213, 215-247, 248-279, 280-312, 313-345, 368-400, 401-432, 433-465, 520-552, 556-588, 589-621
11
0.92
4OE1
B
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
174-208, 209-239, 243-275, 350-384, 385-419, 455-489, 525-552, 561-593, 594-625, 631-663, 667-699
11
0.89
4M59
B
B8Y6I0
Pentatricopeptide repeat-containing protein 10, chloroplastic {ECO:0000303|PubMed:19424177}
Zea mays (Maize)
174-208, 209-239, 243-275, 350-384, 385-419, 455-489, 525-552, 561-593, 594-625, 631-663, 667-699
11
0.89
5ET0
A
Q9ET47
Espin
Mus musculus (Mouse)
1-27, 35-67, 69-101, 103-135, 136-168, 170-202, 204-235, 238-270, 271-302, 303-331
10
0.92
5ET1
A
Q9ET47
Espin
Mus musculus (Mouse)
0-33, 35-67, 69-101, 102-134, 136-168, 170-202, 204-236, 238-270, 271-302, 303-330
10
0.92
5ET1
B
Q9ET47
Espin
Mus musculus (Mouse)
0-33, 35-67, 69-101, 103-135, 137-169, 170-202, 204-236, 238-270, 271-302, 303-330
10
0.92
5ET0
C
Q9ET47
Espin
Mus musculus (Mouse)
35-67, 69-101, 103-135, 137-169, 170-202, 204-236, 238-270, 271-302, 303-331
9
0.92
5MA9
E
-
-
-
13-45, 46-78, 79-111, 112-143, 144-176, 187-212, 222-250, 251-283, 284-309
9
0.84
5MA9
C
-
-
-
13-45, 46-78, 79-110, 111-143, 144-176, 187-212, 224-250, 251-283, 284-309
9
0.84
5MA5
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-177, 187-212, 224-251, 252-284, 285-310
9
0.85
5LE4
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-181, 202-234, 235-267, 268-300, 301-325
9
0.91
5MAK
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-169, 183-208, 220-247, 248-280, 281-305
9
0.84
5LE3
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-174, 193-225, 226-258, 259-291, 292-317
9
0.90
5LEM
A
-
-
-
13-42, 46-78, 79-110, 111-143, 144-181, 203-235, 236-267, 268-300, 301-325
9
0.89
5LE3
C
-
-
-
12-40, 46-78, 79-111, 112-144, 157-185, 193-225, 226-257, 259-291, 292-317
9
0.85
5MAK
C
-
-
-
13-45, 46-78, 79-110, 111-143, 144-169, 183-208, 220-247, 248-280, 281-305
9
0.84
4OAU
C
Q05823
2-5A-dependent ribonuclease
Homo sapiens (Human)
25-51, 58-90, 91-123, 124-155, 166-198, 199-231, 236-268, 269-299, 300-327
9
0.86
5MA5
C
-
-
-
11-45, 46-78, 79-110, 111-143, 144-169, 189-213, 224-251, 252-284, 285-309
9
0.85
5MA3
A
-
-
-
9-45, 46-78, 79-110, 111-143, 144-177, 187-212, 224-251, 252-284, 285-310
9
0.84
4OAV
D
Q05823
2-5A-dependent ribonuclease
Homo sapiens (Human)
26-49, 58-90, 91-123, 124-155, 166-198, 200-232, 236-268, 269-299, 300-327
9
0.85
5LE3
D
-
-
-
13-45, 46-78, 79-111, 112-144, 145-174, 193-225, 226-257, 259-291, 292-317
9
0.89
5MA4
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-176, 177-206, 214-246, 247-279, 281-306
9
0.87
5MA9
G
-
-
-
13-45, 46-78, 79-110, 111-143, 144-176, 187-212, 218-250, 252-284, 285-309
9
0.85
5LE8
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-185, 207-239, 240-271, 272-304, 305-330
9
0.90
5LE7
D
-
-
-
13-45, 46-78, 79-110, 111-143, 144-183, 204-236, 237-269, 270-302, 303-328
9
0.91
5LEA
A
-
-
-
13-45, 46-78, 79-110, 111-143, 144-182, 202-234, 236-268, 269-301, 302-327
9
0.90
5LEN
A
-
-
-
13-45, 46-78, 79-111, 112-143, 144-180, 201-233, 234-266, 267-299, 300-325
9
0.91
3V6T
B
-
-
-
322-352, 425-455, 459-488, 493-525, 562-593, 595-627, 629-661, 663-692, 698-721
9
0.87