Database of Structural Repeats in Proteins

WD40 repeat - WD


WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins.

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InterPro:

IPR001680

PROSITE:

PS50082

SMART:

SM00320

Pfam:

PF00400

Number of PDB chains with WD repeat: 851


1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

1OMW
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-131, 141-180, 182-222, 224-264, 268-309
6
0.93
4J73
A
P41811
Coatomer subunit beta'
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
13-52, 54-94, 95-137, 139-176, 227-267
5
0.93
5IGQ
F
Q8NHY2
E3 ubiquitin-protein ligase RFWD2
Homo sapiens (Human)
419-457, 469-509, 512-551, 554-592
4
0.93
2FAW
A
O81226
Carica papaya (Papaya)
104-143, 151-189, 204-241
3
0.93
5WSG
O
Q12417
Pre-mRNA-splicing factor PRP46
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
138-178, 181-220, 223-262, 265-304, 306-345, 348-388, 397-436
7
0.93
3DWL
C
P78774
Actin-related protein 2/3 complex subunit 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
54-82, 98-129, 144-184
3
0.92
5HE1
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-134, 141-180, 183-222, 224-264, 268-309
6
0.92
4J0X
B
Q06506
Ribosomal RNA-processing protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
235-275, 279-319, 320-360, 397-436
4
0.92
5TZS
g
Q06506
Ribosomal RNA-processing protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
235-275, 279-318, 320-360, 397-436, 470-507
5
0.92
5HE2
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 141-180, 182-222, 224-264, 268-308
6
0.92
2BCJ
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-307
6
0.92
3V5W
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-222, 224-264, 268-309
6
0.92
5KDO
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-128, 141-181, 182-222, 224-264, 268-308
6
0.92
1GOT
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-309
6
0.92
4MK0
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-223, 224-264, 268-309
6
0.91
4QRJ
A
A7VAP0
Bacteroides uniformis (strain ATCC 8492 / DSM 6597 / CIP 103695 / JCM
113-152, 168-207, 217-252, 313-350
4
0.91
3UVK
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 257-298, 300-334
6
0.91
5UKK
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
53-94, 96-133, 182-222, 224-264, 269-308
5
0.91
4QRJ
B
A7VAP0
Bacteroides uniformis (strain ATCC 8492 / DSM 6597 / CIP 103695 / JCM
113-152, 168-207, 217-252, 313-350
4
0.91
2YMU
B
B2J0I0
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
14-54, 55-95, 96-135, 137-176, 179-218, 219-259, 260-299, 302-341, 342-382, 383-423, 425-464, 466-505, 506-546, 547-577
14
0.91
3FVZ
A
P14925
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Rattus norvegicus (Rat)
579-617, 632-672, 684-720
3
0.91
3SOV
A
O75581
Low-density lipoprotein receptor-related protein 6
Homo sapiens (Human)
93-133, 135-173, 180-220
3
0.91
3VH0
D
P76116
Uncharacterized protein YncE
Escherichia coli (strain K12)
88-128, 140-174, 185-223, 229-270, 271-311
5
0.90
3FW0
A
P14925
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase
Rattus norvegicus (Rat)
579-617, 631-672, 684-720, 780-819
4
0.90
3UVN
C
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-209, 223-253, 257-297
6
0.90
2H68
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-298
6
0.90
2CNX
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-210, 223-253, 257-297
6
0.90
3OTT
A
Q89YQ8
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC
91-125, 170-209, 215-248, 348-388, 396-437, 443-482
6
0.90
5EAL
B
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-210, 223-253, 257-297
6
0.90
5IGQ
C
Q8NHY2
E3 ubiquitin-protein ligase RFWD2
Homo sapiens (Human)
424-457, 469-509, 512-553, 554-592
4
0.90
3UVO
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-209, 223-253, 257-298
6
0.90
5VFC
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-297
6
0.90
2CO0
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-210, 223-253, 257-297
6
0.90
5EAM
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-297
6
0.90
2CE9
A
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
482-521, 529-571, 573-612, 614-655, 656-694, 697-737, 738-770
7
0.90
2H6Q
B
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-210, 223-253, 257-298
6
0.90
3VH0
A
P76116
Uncharacterized protein YncE
Escherichia coli (strain K12)
88-128, 140-174, 185-223, 229-270, 271-311
5
0.90
2H6K
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
44-84, 85-126, 127-168, 169-209, 223-253, 257-298
6
0.90
2GNQ
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-298
6
0.90
5UKL
B
P62873
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Homo sapiens (Human)
57-94, 96-133, 141-180, 182-222, 224-264, 268-308
6
0.90
5EAM
B
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 86-126, 127-168, 169-209, 223-253, 257-297
6
0.90
3VH0
B
P76116
Uncharacterized protein YncE
Escherichia coli (strain K12)
88-128, 182-219, 230-264, 271-307
4
0.90
2CE8
A
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
482-521, 529-571, 573-612, 614-655, 656-694, 697-737, 738-770
7
0.90
2H6K
B
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-168, 169-209, 223-253, 257-298
6
0.90
3OW8
B
Q9GZS3
WD repeat-containing protein 61, N-terminally processed
Homo sapiens (Human)
62-103, 104-145, 146-186, 188-228, 231-270, 272-304
6
0.90
2CE9
C
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
482-521, 529-571, 573-612, 614-655, 656-694, 696-737, 738-770
7
0.90
4J0W
A
O43818
U3 small nucleolar RNA-interacting protein 2
Homo sapiens (Human)
144-184, 197-237, 240-280, 281-321, 322-361, 375-411, 420-455
7
0.90
3UVN
A
P61964
WD repeat-containing protein 5
Homo sapiens (Human)
43-84, 85-126, 127-167, 169-209, 223-253, 257-298
6
0.90
5MWJ
B
Q04724
Transducin-like enhancer protein 1
Homo sapiens (Human)
573-612, 656-694, 697-737, 738-770
4
0.89
3KRX
B
P62871
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Bos taurus (Bovine)
53-94, 96-133, 141-181, 182-222, 224-264, 268-309, 311-340
7
0.89