Database of Structural Repeats in Proteins

Pumilio repeat - Pumilio


The Drosophila pumilio gene codes for an unusual protein that binds through the Puf domain that usually occurs as a tandem repeat of eight domains. The FBF-2 protein of Caenorhabditis elegans also has a Puf domain. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs. The same type of repetitive domain has been found in in a number of other proteins from all eukaryotic kingdoms. The Puf proteins characterised to date have been reported to bind to 3'-untranslated region (UTR) sequences encompassing a so-called UGUR tetranucleotide motif and thereby to repress gene expression by affecting mRNA translation or stability.

Link to other db

InterPro:

IPR001313

PROSITE:

PS50302

SMART:

SM00025

Pfam:

PF00806

Number of PDB chains with Pumilio repeat: 84


1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

3BSX
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.95
3Q0N
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-955, 956-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
1M8X
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-884, 885-921, 922-957, 958-992, 993-1018, 1019-1065, 1066-1103, 1107-1145
8
0.95
3Q0O
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
2YJY
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1103
6
0.95
3Q0L
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-955, 956-992, 993-1030, 1031-1065, 1066-1103, 1106-1145
8
0.95
5KLA
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1138-1184, 1185-1219, 1220-1256, 1282-1327, 1328-1366, 1367-1405
6
0.95
3Q0O
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-957, 958-993, 1019-1065, 1066-1103
5
0.95
2YJY
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1133
6
0.95
1M8W
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
1M8W
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
7
0.95
3Q0P
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-992, 993-1031, 1032-1065, 1066-1103, 1107-1145
8
0.95
3Q0N
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
885-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1145
6
0.95
3K4E
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-717, 718-747, 748-795, 808-835
8
0.94
3Q0Q
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
6
0.94
5KL1
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1150-1184, 1185-1220, 1221-1255, 1256-1281, 1282-1327, 1328-1364, 1367-1402
7
0.94
3Q0L
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1147
6
0.94
3Q0R
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
728-765, 766-799, 800-836, 837-873, 899-945, 946-983, 986-1025
7
0.94
3BSX
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-921, 922-957, 958-993, 1019-1065, 1066-1102, 1105-1145
6
0.94
5KL8
A
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
1148-1183, 1184-1219, 1220-1254, 1255-1281, 1282-1327, 1328-1365, 1367-1402
7
0.94
1M8Y
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
7
0.94
3Q0S
A
Q8TB72
Pumilio homolog 2
Homo sapiens (Human)
727-752, 753-799, 800-836, 837-873, 874-911, 912-945, 946-983, 986-1027
8
0.94
3BX2
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
590-637, 638-674, 675-701, 702-747, 748-776
5
0.94
3Q0M
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
850-886, 887-921, 922-956, 957-993, 994-1031, 1032-1065, 1066-1101, 1106-1143
8
0.94
3K4E
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
3Q0P
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-957, 958-993, 1019-1065, 1066-1103, 1107-1145
6
0.94
3BSB
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
848-887, 888-921, 922-956, 957-993, 1019-1065, 1066-1101, 1107-1145
7
0.94
1M8Z
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1142
7
0.94
3BX3
B
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
602-637, 638-664, 665-698, 699-746, 747-775, 776-822, 823-852
7
0.94
3K4E
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
538-575, 576-611, 612-647, 648-682, 683-718, 719-747, 748-795, 808-835
8
0.94
3BSB
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
875-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
6
0.94
1M8X
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1106-1145
6
0.94
5BYM
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-438, 439-472
6
0.94
3K49
A
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-679, 683-718, 719-747, 764-795, 809-835
8
0.93
3K49
C
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
5BZ5
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-439, 440-472
6
0.93
3GVT
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
766-799, 800-828, 837-873, 899-945, 946-983, 987-1027
6
0.93
1IB2
A
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
849-886, 887-921, 922-956, 957-993, 1019-1065, 1066-1103, 1107-1143
7
0.93
3K49
E
Q07807
mRNA-binding protein PUF3
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
539-576, 577-611, 612-647, 648-682, 683-718, 719-747, 764-795, 809-835
8
0.93
5BZU
A
P39016
Suppressor protein MPT5
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
251-286, 287-322, 326-365, 366-391, 392-439, 440-472
6
0.93
3GVT
B
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
728-765, 766-799, 800-828, 837-872, 873-898, 899-945, 946-983, 987-1027
8
0.93
3BX3
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
564-601, 602-637, 638-664, 665-698, 699-746, 747-775, 787-822, 823-852
8
0.93
3H3D
X
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
47-82, 83-129, 130-165, 166-204, 205-237, 238-274, 276-311
7
0.93
3H3D
Y
P25822
Maternal protein pumilio
Drosophila melanogaster (Fruit fly)
361-396, 397-442, 443-479, 480-507, 508-551, 552-587, 590-625
7
0.93
3GVO
A
Q80U58
Pumilio homolog 2
Mus musculus (Mouse)
727-764, 765-799, 800-828, 838-873, 899-944, 945-983, 987-1025
7
0.92
3QGB
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 283-308, 309-348, 349-382, 411-439, 440-478, 485-520
7
0.92
3K61
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
230-260, 276-308, 310-348, 349-382, 411-439, 440-478, 485-520
7
0.92
3QGC
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
229-260, 283-308, 310-348, 349-383, 411-439, 440-478, 485-520
7
0.92
1M8Y
B
Q14671
Pumilio homolog 1 {ECO:0000305}
Homo sapiens (Human)
888-920, 921-955, 956-993, 994-1031, 1032-1065, 1066-1096, 1106-1141, 1142-1169
8
0.91
4DZS
B
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
569-599, 600-637, 638-674, 675-701, 702-734
5
0.89