Database of Structural Repeats in Proteins

Leucine-rich repeat - LRR


Leucine-rich repeats consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions.Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response.

Link to other db

InterPro:

IPR001611

PROSITE:

PS51450

Pfam:

PF00560

Number of PDB chains with LRR repeat: 4696


1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

4Z61
C
Q9XIC7
Somatic embryogenesis receptor kinase 2
Arabidopsis thaliana (Mouse-ear cress)
99-120, 123-144, 147-168, 171-192
4
0.94
1FT8
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.94
3RW6
B
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.94
5IL7
B
Q8KC98
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 /
38-61, 64-85, 86-107, 108-129, 130-151, 152-173, 174-195, 196-217, 218-239, 240-261, 262-283, 284-305, 306-327, 328-349, 350-371, 373-394
16
0.94
3E4G
A
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
62-82, 85-107, 115-136, 139-164
4
0.94
4U08
B
Q72TC3
Leptospira interrogans serogroup Icterohaemorrhagiae serovar
49-70, 73-94, 96-118, 119-140, 142-163, 165-186, 188-209, 211-232, 234-255, 257-278, 280-301, 303-324, 326-347, 349-370, 372-393, 395-417
16
0.94
3E2J
B
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
61-82, 85-107, 115-136, 139-163
4
0.94
4Q3G
B
Q7XV05
LRR receptor kinase SERK2 {ECO:0000305}
Oryza sativa subsp
101-122, 125-146, 149-170, 173-194
4
0.94
3DZE
A
P22027
ATP synthase subunit s, mitochondrial
Bos taurus (Bovine)
62-82, 85-107, 115-136, 139-164
4
0.94
5IYX
A
P47735
Receptor-like protein kinase 5
Arabidopsis thaliana (Mouse-ear cress)
67-89, 92-113, 117-138, 142-163, 166-187, 190-211, 215-236, 239-260, 263-284, 287-308, 310-331, 381-402, 404-425, 428-449, 452-473, 477-498, 501-522, 525-546, 549-570, 572-592
20
0.93
2O6Q
A
Q32R26
Eptatretus burgeri (Inshore hagfish)
38-60, 62-83, 86-107, 110-131, 132-153, 156-177, 180-201, 204-225, 228-245
9
0.93
4U08
A
Q72TC3
Leptospira interrogans serogroup Icterohaemorrhagiae serovar
49-70, 73-94, 96-118, 119-140, 142-163, 165-186, 188-209, 211-232, 235-256, 257-278, 280-301, 303-324, 326-347, 349-370, 372-393, 395-417
16
0.93
4FHO
A
-
-
-
79-100, 101-121, 122-142, 143-164, 165-186, 187-208, 209-230, 231-252
8
0.93
2OMX
A
P0DJM0
Internalin-A
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-122, 123-144, 145-164, 165-186, 187-208, 209-230, 231-252, 253-274, 275-296, 297-318, 319-340, 341-362, 363-384, 385-406
15
0.93
2Z82
A
Q9QUN7
Toll-like receptor 2
Mus musculus (Mouse)
32-52, 101-122, 125-146, 198-219, 224-245, 251-275, 309-330, 337-358, 361-382, 388-409, 414-435, 437-458, 459-479, 480-499, 500-521, 524-541
16
0.93
1FS2
A
Q13309
S-phase kinase-associated protein 2
Homo sapiens (Human)
218-239, 242-266, 269-292, 296-320, 323-344, 348-370, 372-394
7
0.93
4Z61
D
Q9XIC7
Somatic embryogenesis receptor kinase 2
Arabidopsis thaliana (Mouse-ear cress)
73-96, 99-120, 123-144, 147-168, 171-192
5
0.93
5GR9
B
Q9FII5
Leucine-rich repeat receptor-like protein kinase TDR
Arabidopsis thaliana (Mouse-ear cress)
83-105, 108-129, 132-153, 156-177, 180-201, 204-225, 228-249, 252-273, 276-297, 300-321, 324-345, 348-369, 372-393, 396-417, 420-441, 443-464, 467-488, 491-512, 514-535, 538-559, 562-583, 586-607
22
0.93
1OTO
A
P25147
Internalin B
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-120, 121-142, 143-164, 165-186, 187-208, 209-230
7
0.93
3RW7
B
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
4FHO
B
-
-
-
79-100, 101-120, 121-142, 143-164, 165-186, 187-208, 209-230, 231-252
8
0.93
2OMY
A
P0DJM0
Internalin-A
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-121, 122-142, 143-164, 165-186, 187-207, 208-229, 230-251, 252-273, 274-295, 296-317, 318-339, 340-361, 362-383, 384-405
15
0.93
5LFN
C
O15335
Chondroadherin
Homo sapiens (Human)
31-52, 54-75, 78-99, 102-123, 126-147, 150-171, 174-195, 196-217, 220-242, 245-266, 269-290, 291-317
12
0.93
1FS2
C
Q13309
S-phase kinase-associated protein 2
Homo sapiens (Human)
218-239, 242-266, 269-292, 296-320, 323-344, 348-370, 373-394
7
0.93
3ZYI
A
Q9HBW1
Leucine-rich repeat-containing protein 4
Homo sapiens (Human)
55-76, 77-96, 99-120, 124-145, 148-169, 172-193, 197-218, 219-240, 243-264, 267-288, 333-354
11
0.93
2OMT
A
P0DJM0
Internalin-A
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-122, 123-144, 145-165, 166-186, 187-208, 209-230, 231-252, 253-274, 275-296, 297-318, 319-340, 341-362, 363-384, 385-406
15
0.93
3OJA
B
-
-
-
227-248, 251-272, 275-296, 299-320, 360-381, 382-403, 429-451, 452-473, 474-494
9
0.93
1KOO
D
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-287, 292-313, 315-334
3
0.93
2V70
B
O94813
Slit homolog 2 protein C-product
Homo sapiens (Human)
514-534, 536-557, 561-582, 585-606, 608-629, 631-652, 655-681
7
0.93
4U09
A
Q72NS0
Leptospira interrogans serogroup Icterohaemorrhagiae serovar
43-63, 65-86, 88-109, 111-132, 134-155, 157-178, 180-202, 203-224, 227-249, 251-272, 273-293, 295-316, 318-339, 341-362, 364-385, 387-409
16
0.93
4BV4
R
P08953
Protein toll
Drosophila melanogaster (Fruit fly)
99-122, 126-146, 150-171, 175-196, 198-219, 222-243, 246-267, 270-291, 294-315, 319-340, 342-363, 367-388, 391-412, 415-432
14
0.93
4Z5W
B
Q8LPB4
Phytosulfokine receptor 1
Daucus carota (Wild carrot)
86-110, 113-134, 185-206, 209-230, 231-252, 279-300, 327-348, 351-372, 375-397, 401-422, 426-447, 452-473, 476-496, 536-557, 560-581, 583-604, 607-629
17
0.93
5JH5
A
Q8NHM5
Lysine-specific demethylase 2B
Homo sapiens (Human)
1102-1124, 1125-1147, 1150-1171, 1174-1196, 1214-1236, 1239-1260, 1270-1290, 1294-1317
8
0.93
3RW7
C
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
222-243, 266-289, 292-313, 316-333
4
0.93
5GIJ
B
Q9FII5
Leucine-rich repeat receptor-like protein kinase TDR
Arabidopsis thaliana (Mouse-ear cress)
83-105, 108-129, 132-153, 156-177, 180-201, 204-225, 228-249, 252-273, 276-297, 300-321, 324-345, 370-391, 394-415, 418-439, 442-463, 467-488, 513-534, 537-558, 561-582
19
0.93
3V44
A
Q4G1L2
Eptatretus burgeri (Inshore hagfish)
26-48, 49-69, 99-120, 123-144, 147-169, 172-194, 198-217, 230-253, 293-314, 317-338, 341-362, 365-382
12
0.93
1FT8
A
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
3ZYJ
A
Q9HCJ2
Leucine-rich repeat-containing protein 4C
Homo sapiens (Human)
56-77, 78-98, 101-122, 126-147, 149-170, 173-194, 198-219, 220-241, 244-265, 268-289, 292-308
11
0.93
2OMU
A
P0DJM0
Internalin-A
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
79-100, 101-122, 123-144, 145-164, 165-186, 187-208, 209-230, 231-252, 253-274, 275-296, 297-318, 319-340, 341-362, 363-384, 385-406
15
0.93
1XEU
A
Q8Y6A8
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
78-99, 100-121, 122-141, 142-162, 163-184, 185-206
6
0.93
4LSC
A
Q94AG2
Somatic embryogenesis receptor kinase 1
Arabidopsis thaliana (Mouse-ear cress)
70-93, 96-117, 120-141, 144-165, 168-189
5
0.93
2Z7X
A
O60603
Toll-like receptor 2
Homo sapiens (Human)
52-73, 100-121, 125-146, 198-219, 222-243, 249-274, 309-331, 337-358, 361-382, 388-409, 414-435, 437-458, 459-479, 480-499, 500-521, 524-541
16
0.93
4Z63
A
Q9ZVR7
Phytosulfokine receptor 1 {ECO:0000303|PubMed:16829587}
Arabidopsis thaliana (Mouse-ear cress)
77-100, 103-124, 127-148, 150-171, 175-196, 199-220, 223-244, 247-268, 271-292, 317-338, 341-362, 365-387, 393-414, 418-439, 442-463, 466-486, 526-547, 550-571, 574-595, 598-619
20
0.93
2V70
C
O94813
Slit homolog 2 protein C-product
Homo sapiens (Human)
514-534, 536-557, 561-582, 583-604, 608-629, 631-652, 655-681
7
0.93
1OGQ
A
P58822
Polygalacturonase inhibitor 2
Phaseolus vulgaris (Kidney bean) (French bean)
104-125, 128-149, 152-173, 177-198, 200-221, 224-245, 247-268
7
0.93
2ID5
A
Q96FE5
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Homo sapiens (Human)
12-33, 34-54, 57-78, 81-102, 105-126, 128-149, 152-173, 177-198, 201-222, 227-248, 249-270, 273-294, 297-318, 322-343
14
0.93
1FT8
B
Q9UBU9
Nuclear RNA export factor 1
Homo sapiens (Human)
266-289, 292-313, 316-333
3
0.93
3ZYN
B
P0C192
Leucine-rich repeat-containing protein 4B
Mus musculus (Mouse)
67-87, 89-110, 113-134, 137-158, 161-182, 185-206, 210-231, 232-253, 257-278, 280-301, 305-331, 346-366
12
0.93
4Z64
A
Q9ZVR7
Phytosulfokine receptor 1 {ECO:0000303|PubMed:16829587}
Arabidopsis thaliana (Mouse-ear cress)
79-100, 103-124, 127-148, 150-171, 175-196, 199-220, 223-244, 247-268, 271-292, 318-339, 341-362, 365-387, 391-412, 416-437, 441-462, 465-486, 526-547, 549-570, 573-594, 597-619
20
0.93
2V70
D
O94813
Slit homolog 2 protein C-product
Homo sapiens (Human)
514-534, 536-557, 561-582, 585-606, 608-629, 631-652, 655-681
7
0.93