Database of Structural Repeats in Proteins

Kelch repeat - Kelch


Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified. This sequence motif represents one beta-sheet blade, and several of these repeats can associate to form a beta-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein, creating a 6-bladed beta-propeller. The motif is also found in mouse protein MIPP and in a number of poxviruses. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold. The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function.

Link to other db

InterPro:

IPR006652

SMART:

SM00612

Pfam:

PF01344

Number of PDB chains with Kelch repeat: 71


1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

4N1B
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-362, 424-470, 471-517, 518-557, 565-610
5
0.85
4L7C
C
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-470, 471-517, 518-564, 565-603
5
0.85
5X54
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-517, 518-564, 565-609
5
0.85
3VNG
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
5-41, 103-142, 150-196, 197-243, 244-288
5
0.85
4L7D
C
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-470, 471-517, 518-564, 565-603
5
0.85
3ZGD
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-517, 518-564, 565-602
5
0.83
5NKP
B
Q9UH77
Kelch-like protein 3
Homo sapiens (Human)
301-340, 348-384, 395-441, 442-477, 491-537, 538-584
6
0.83
2FLU
X
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-517, 518-564, 565-602
5
0.83
4IFN
X
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-517, 518-564, 565-602
5
0.83
3ZGD
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-517, 518-564, 565-602
5
0.83
5CGJ
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 424-463, 471-517, 518-564, 565-603
5
0.83
4IQK
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-517, 518-564, 565-602
5
0.82
4N1B
C
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-470, 471-517, 518-564, 565-602
6
0.82
4CH9
B
Q9UH77
Kelch-like protein 3
Homo sapiens (Human)
301-337, 348-384, 395-441, 442-477, 491-537, 538-584
6
0.82
3ZGC
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 373-408, 424-463, 471-517, 518-564, 565-609
6
0.82
4L7B
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-517, 518-564, 565-602
5
0.82
3VNH
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
6-40, 103-142, 150-189, 197-243, 244-288
5
0.82
2Z32
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.81
4L7B
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-470, 471-517, 518-564, 565-602
6
0.81
4CHB
A
O95198
Kelch-like protein 2
Homo sapiens (Human)
307-346, 354-390, 401-447, 448-483, 497-536, 544-590
6
0.81
3ZGC
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-510, 518-564, 565-603
5
0.81
4CHB
B
O95198
Kelch-like protein 2
Homo sapiens (Human)
307-346, 354-390, 401-440, 454-495, 497-536, 544-590
6
0.81
5FNU
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-517, 518-564, 565-603
6
0.80
4CH9
A
Q9UH77
Kelch-like protein 3
Homo sapiens (Human)
301-337, 348-384, 395-441, 442-477, 491-530, 538-584
6
0.80
4L7D
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-510, 518-557, 565-610
5
0.80
4ZY3
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.80
4IN4
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-463, 471-517, 518-557, 565-609
6
0.80
2XN4
A
O95198
Kelch-like protein 2
Homo sapiens (Human)
307-342, 354-390, 401-440, 454-495, 497-536, 544-590
6
0.80
1X2R
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-517, 518-564, 565-603
6
0.80
5FNS
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.80
4L7C
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-510, 518-564, 565-602
5
0.80
4IN4
C
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.80
5F72
C
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 424-463, 471-510, 518-564, 565-601
5
0.79
4ZGC
A
Q8IDQ2
Plasmodium falciparum (isolate 3D7)
444-480, 539-585, 586-624, 633-673, 681-719
5
0.79
2DYH
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.79
4L7D
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.79
4ZGC
B
Q8IDQ2
Plasmodium falciparum (isolate 3D7)
444-480, 539-578, 586-624, 633-679
4
0.79
1U6D
X
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 424-463, 471-510, 518-564, 565-602
5
0.79
4L7C
A
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
327-361, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.79
2XN4
B
O95198
Kelch-like protein 2
Homo sapiens (Human)
307-346, 354-390, 401-440, 448-483, 497-536, 544-590
6
0.79
3WDZ
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
327-361, 373-408, 424-463, 471-517, 518-564, 565-602
6
0.79
5FNT
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.78
4IFL
X
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.78
5F72
K
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 373-408, 424-463, 471-510, 518-564, 565-602
6
0.78
3WN7
L
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.78
5FZJ
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.78
5FNQ
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-602
6
0.78
5X54
B
Q14145
Kelch-like ECH-associated protein 1
Homo sapiens (Human)
326-362, 373-408, 424-463, 471-510, 518-564, 565-603
6
0.78
1X2J
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-602
6
0.78
5FZN
A
Q9Z2X8
Kelch-like ECH-associated protein 1
Mus musculus (Mouse)
326-362, 373-408, 424-463, 471-510, 518-564, 565-602
6
0.78