Database of Structural Repeats in Proteins

Hemopexin-like repeats - Hemopexin


Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. The hemopexin domain exhibits the shape of an oblate ellipsoidal disk. The polypeptide chain is organised in four beta-sheet (blades) I to IV, which are almost symmetrically arranged around a central axis in consecutive order, giving rise to the formation of a four-bladed propeller. Each propeller blade or repeat is made up of four antiparallel beta-strands connected in a W-like strand topology, and is strongly twisted.

Link to other db

InterPro:

IPR018487

PROSITE:

PS51642

SMART:

SM00120

Pfam:

PF00045

Number of PDB chains with Hemopexin repeat: 27


1 - 27

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

4G0D
C
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 331-374, 379-423, 428-471
4
0.94
1SU3
A
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
325-368, 374-417, 423-466
3
0.94
1SU3
B
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
325-368, 374-417, 423-465
3
0.93
1PEX
A
P45452
Collagenase 3
Homo sapiens (Human)
281-324, 325-369, 374-418, 423-466
4
0.93
4AUO
A
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
262-305, 306-349, 355-398, 404-447
4
0.93
2CLT
B
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
262-305, 306-349, 355-399, 404-447
4
0.93
4AUO
B
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
262-305, 307-350, 355-398, 404-447
4
0.93
1GEN
A
P08253
PEX
Homo sapiens (Human)
472-515, 518-561, 565-608
3
0.93
4G0D
D
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.92
4FVL
A
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.92
4FVL
B
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.92
1FBL
A
P21692
18 kDa interstitial collagenase
Sus scrofa (Pig)
281-324, 330-369, 374-418, 423-466
4
0.92
2JXY
A
P39900
Macrophage metalloelastase
Homo sapiens (Human)
285-328, 330-373, 377-421, 426-469
4
0.92
1QJS
A
P20058
Hemopexin
Oryctolagus cuniculus (Rabbit)
30-73, 74-114, 162-205, 238-277, 278-322, 330-373
6
0.92
3BA0
A
P39900
Macrophage metalloelastase
Homo sapiens (Human)
285-328, 334-373, 377-420, 426-469
4
0.92
4FU4
A
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.92
3OYO
A
F2Z290
Vigna unguiculata (Cowpea)
3-46, 61-103, 117-160
3
0.91
4G0D
A
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.91
4G0D
B
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 379-423, 428-471
4
0.91
3LP9
D
D4AEP7
Albumin-2 {ECO:0000250|UniProtKB:P08688}
Lathyrus sativus (Chickling vetch)
63-103, 118-161, 176-213
3
0.90
1HXN
A
P20058
Hemopexin
Oryctolagus cuniculus (Rabbit)
232-275, 277-321, 334-373
3
0.90
2CLT
A
P03956
27 kDa interstitial collagenase
Homo sapiens (Human)
262-305, 311-350, 360-399, 404-447
4
0.90
4FU4
B
P45452
Collagenase 3
Homo sapiens (Human)
287-330, 336-375, 384-423, 428-471
4
0.89
1QHU
A
P20058
Hemopexin
Oryctolagus cuniculus (Rabbit)
30-73, 162-205, 232-275, 277-314, 329-372
5
0.89
1CK7
A
P08253
PEX
Homo sapiens (Human)
522-561, 566-609, 615-658
3
0.88
4E54
A
Q16531
DNA damage-binding protein 1
Homo sapiens (Human)
407-450, 456-499, 500-536, 870-907, 908-951
5
0.85
1GXD
A
P08253
PEX
Homo sapiens (Human)
493-532, 541-580, 585-628
3
0.85