Database of Structural Repeats in Proteins

HEAT repeat - HEAT


The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes. The HEAT repeats consist of pairs of antiparallel alpha helices.

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InterPro:

IPR000357

Pfam:

PF02985

Number of PDB chains with HEAT repeat: 856


1 - 50

PDB

Chain

UniProt

Name

Organism

Repeat annotation

Copies

Score

1JK0
B
P49723
Ribonucleoside-diphosphate reductase small chain 2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
100-142, 153-189, 190-235
3
0.91
2KM4
A
Q05543
Regulator of Ty1 transposition protein 103
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
5-51, 54-99, 100-138
3
0.91
3VYC
A
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
130-167, 177-225, 336-376, 479-520, 521-568, 563-611, 615-657, 686-745, 827-876, 1003-1040
10
0.91
3NMZ
B
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
377-427, 471-512, 513-556, 557-599, 600-647, 648-690, 691-732
7
0.91
2R17
D
Q96QK1
Vacuolar protein sorting-associated protein 35
Homo sapiens (Human)
503-548, 552-596, 597-641, 642-678
4
0.91
2Y3U
A
Q9X721
Hathewaya histolytica (Clostridium histolyticum)
160-202, 212-255, 256-301
3
0.91
5CLC
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.90
5DLQ
A
Q9ESJ0
Exportin-4
Mus musculus (Mouse)
47-84, 85-129, 130-168, 184-238, 263-307, 673-713, 826-869
7
0.90
3NMX
C
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-599, 609-649, 650-690, 691-732
6
0.90
4K92
B
Q7Z460
CLIP-associating protein 1
Homo sapiens (Human)
317-360, 412-443, 444-479, 482-517
4
0.90
2NPP
B
Q13362
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Homo sapiens (Human)
142-184, 185-227, 228-269, 270-303
4
0.90
5IZ6
A
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-599, 609-647, 648-690, 691-732
6
0.90
4UQI
A
P18484
AP-2 complex subunit alpha-2
Rattus norvegicus (Rat)
71-105, 106-140, 141-183, 184-222, 519-552, 553-591
6
0.90
4FZD
A
Q9Y376
Calcium-binding protein 39
Homo sapiens (Human)
77-111, 123-162, 163-195, 251-288
4
0.89
5UUH
A
C2T7T7
Bacillus cereus BDRD-Cer4
93-127, 128-162, 163-196
3
0.89
5CL6
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
3ZJY
B
O94829
Importin-13
Homo sapiens (Human)
55-90, 93-135, 184-235, 236-274, 276-325, 523-562, 563-602, 676-719, 805-848, 910-951
10
0.89
5JZZ
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 410-451, 452-485
3
0.89
1X81
A
Q04631
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Rattus norvegicus (Rat)
94-144, 200-248, 249-288, 289-327
4
0.89
5CL7
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
4YJE
A
P25054
Adenomatous polyposis coli protein
Homo sapiens (Human)
471-512, 513-556, 557-598, 609-649, 650-690, 691-733
6
0.89
4K92
A
Q7Z460
CLIP-associating protein 1
Homo sapiens (Human)
317-360, 412-443, 444-479, 482-517
4
0.89
5CL8
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5CL3
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5DLQ
B
Q9ESJ0
Exportin-4
Mus musculus (Mouse)
47-84, 85-129, 130-167, 185-238, 263-307, 603-650, 722-763, 826-869, 949-991, 993-1034
10
0.89
3SPY
A
Q38087
DNA-directed DNA polymerase {ECO:0000255|HAMAP-Rule:MF_04100}
Enterobacteria phage RB69 (Bacteriophage RB69)
468-506, 524-570, 571-609, 729-773
4
0.89
5JQY
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.89
5UUF
A
C2T7T7
Bacillus cereus BDRD-Cer4
93-127, 128-162, 163-196
3
0.89
5CL4
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
2DB0
A
O58277
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /
29-63, 64-115, 116-153, 181-212
4
0.89
5CLA
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5JZ8
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-451, 452-485
3
0.89
1W9C
A
O14980
Exportin-1
Homo sapiens (Human)
736-767, 866-907, 908-956, 970-1024
4
0.89
5CL5
A
Q816E8
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 /
93-127, 128-162, 163-196
3
0.89
5VOX
P
P41807
V-type proton ATPase subunit H
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
23-55, 73-110, 120-157, 167-204, 445-478
5
0.88
3WYF
F
P30822
Exportin-1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
44-81, 84-131, 132-170, 176-225, 334-376, 479-520, 521-568, 563-611, 615-657, 780-826, 827-876, 922-968, 1003-1040
13
0.88
2Z5J
A
Q92973
Transportin-1
Homo sapiens (Human)
45-83, 128-167, 171-206, 251-289, 430-473, 477-517, 518-558, 705-745, 787-830
9
0.88
2NPP
D
P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Homo sapiens (Human)
8-43, 83-120, 121-157, 160-197, 198-234, 237-275, 317-357, 358-395, 397-435, 436-474, 480-513, 514-552, 553-589
13
0.88
3J9T
P
P41807
V-type proton ATPase subunit H
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
23-55, 73-110, 120-157, 167-196, 393-436, 445-478
6
0.88
4YV6
D
A0A0J9X288
Streptococcus dysgalactiae
72-121, 115-156, 157-200, 201-240
4
0.88
5ME3
B
Q750S2
Sister chromatid cohesion protein 2
Ashbya gossypii (strain ATCC 10895 / CBS 109
461-519, 679-722, 716-752, 753-788, 968-1010, 1113-1154, 1208-1246, 1309-1353
8
0.88
2JKT
L
P17427
AP-2 complex subunit alpha-2
Mus musculus (Mouse)
71-105, 106-140, 141-183, 184-221, 415-451, 520-558
6
0.88
3BWT
A
P25339
Pumilio homology domain family member 4
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
625-662, 663-698, 699-734, 735-773, 774-808, 809-851
6
0.88
5JZU
A
Q12797
Aspartyl/asparaginyl beta-hydroxylase
Homo sapiens (Human)
355-393, 411-450, 451-485
3
0.88
3K62
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
384-424, 425-464, 479-516
3
0.88
1OYZ
A
P0ADK6
Protein YibA
Escherichia coli (strain K12)
51-86, 87-122, 123-155, 187-221
4
0.88
3A9C
C
Q5JFM9
Ribose 1,5-bisphosphate isomerase
Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
5-43, 45-86, 90-127
3
0.88
1QGK
A
Q14974
Importin subunit beta-1
Homo sapiens (Human)
33-69, 85-126, 127-165, 169-210, 212-257, 258-303, 399-443, 500-540, 661-701, 745-782, 839-876
11
0.88
3QGB
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
299-336, 384-424, 425-464, 479-516
4
0.88
3K64
A
Q09312
Fem-3 mRNA-binding factor 2
Caenorhabditis elegans
384-424, 425-464, 479-516
3
0.88